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Anadrol
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Anadrol - 08-08-2004, 01:41 AM

ANADROL - OXYMETHELONE -

17 beta-hydroxy-2-hydroxymethylene-17alpha-methyl-5 alpha-androstan-3-one


Common Dosage Schemes: 25-200mg day


Anadrol, also known by its common pharmaceutical name of Oxymethelone, is one of the most potent steroids ever produced and marketed. Anadrol has an extreme androgenic effect, and uniquely, also has an extreme anabolic effect. Produced as an oral steroid, it has been 17 alpha alkylated to bypass destruction upon being processed by the liver. It is one of the only steroids know to have caused significant liver damage, and in one reported case, liver failure. However, the user should not be concerned about permanent or even significant temporary side-effects if a reasonable dosage for a period not exceeding 6-8 weeks is followed.


Due to Anadrol’s highly androgenic effect, and its potent anabolic activity, one can expect very large strength and muscle increases in a very short period. A weight gain of 20lbs within 3-5 weeks is not unusual, even for advanced athletes. The large weight gain is largely composed of considerable water retention, creating a large “puffy” look to the users physique. Thus, Anadrol is used primarily in bulking cycles, and serves almost no purpose if an athlete is looking for lean muscle gains, or a hardening effect.

Anadrol’s intended use is the treatment of Anemia, which is characterized by low red blood cell count. Due to this, Anadrol is extremely effective in boosting ones endurance, by the increased buildup of red blood cells. An athlete using Anadrol will notice this during intense training, as this drug produces a very significant “pump”. The increased endurance caused by this drug will also allow the user to train significantly longer, and with much higher intensity.

Anadrol, like many other steroids, has a significant estrogenic effect, which must not be overlooked if its use is considered. Unlike similar steroids, such as Dianabol (methandrostenelone), Oxymethelone does not aromatize. Rather, is actually activates the estrogen receptor. This is largely in part due to the fact that Oxymethelones structure is somewhat similar to that of estradiol. One can combat Anadrol’s highly estrogenic effects by using Nolvadex (tamoxifen citrate). Tamoxifen will bind to estrogen receptors, disallowing their activation, is some tissues, by Anadrol. However, the use of Aromatase Inhibitors like Arimidex ( Anastrozole) or Femara (letrozole) are ineffective in combating estrogen activation from Oxymethelone, as this drug does not aromatize.

-Heavy
   
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08-12-2004, 02:28 AM

Anadrol 50 is the U.S. brand name for oxymetholone, a very potent oral androgen. This compound was first made available in 1960, by the international drug firm Syntex. Since oxymetholone has the beneficial effect of increasing red blood cell production, it showed particular promise in treating cases of severe anemia. For this purpose it was well suited, and was popular for quite some time. But recent years have brought fourth a number of new treatments, most notably the non-steroidal hormone Epogen (erythropoietin). This item is shown to have a much more direct effect on the red blood cell count, without the side effects of a strong androgen. Financial disinterest finally prompted Syntex to halt production of the U.S. Anadrol 50 in 1993, which was around the same time they decided to drop this item in a number of foreign countries. Plenastril from Switzerland and Austria was dropped; following soon was Oxitosona from Spain. Many Athletes feared Anadrol 50 might be on the way out for good. But new HIV/AIDS studies have shown anew light on oxymetholone. These studies are finding (big surprise) exceptional anti-wasting properties to the compound and believe it can be used safely in many such cases. Interest has been peaked, and as of 1998 Anadrol 50 is again being sold in the United States. This time we see the same Anadrol 50 brand name, but the manufacturer is the drug firm Unimed. Syntex is still the world producer of the drug and continues to market & license it a number of countries (under a few different brand names).

Anadrol 50 is considered by many to be the most powerful steroid available. The results of this compound can be extremely dramatic. A steroid novice experimenting with oxymetholone is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished in less than 6 weeks, with only one or two tablets per day. This steroid produces a lot of trouble with water retention, so let there be little doubt that much of this gain is simply bloat. But for the user this is often little consequence, feeling bigger and stronger on Anadrol 50 than any steroid they are likely to cross. Although the smooth look that results from water retention is often not attractive, it can aid quite a bit to the level of size and strength gained. The muscle is fuller, will contract better and is provided a level of protection in the form of "lubrication" to the joints as some of this extra water is held into and around connective tissues. This will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavy. It should be noted however, that on the other hand the very rapid gain in mass might place too much stress on your connective tissues for this to compensate. The tearing of pectoral and biceps tissue is commonly associated with heavy lifting while massing up on heavy androgens. There is such a thing as gaining too fast. Pronounced estrogen trouble also puts the user at risk for developing gynecomastia. Individuals sensitive to the effects of estrogen, or looking to retain a more quality look, will therefore often add Nolvadex to each cycle. It is important to note however, that this drug does not directly convert to estrogen in the body. Anadrol 50 is a derivative of I dihydrotestosterone, and as such has a structure that cannot be aromatized. It may turn out that a metabolite converts to estrogen, or more likely its estrogenic activity is made present through some other mechanism. The strong anti-aromatase compounds Cytadren and ArimideX may therefore prove less than useful with Anadrol 50 (I would be curious to hear reports).

Anadrol 50 is also a very potent androgen. This trait tends to produce many pronounced, unwanted androgenic side effects. Oil skin, acne and body/facial hair growth can be seen very quickly with this drug. Many individuals respond with severe acne, often requiring medication to keep it under control. Some of these individuals find that Accutaine works well, which is a strong prescription drug that acts on the sebaceous glands to reduce the release of oils. And while some very adventurous female athletes do experiment with this compound, it is much too androgenic to recommend. Irreversible virilization symptoms can be the result and may occur very quickly, possibly before you have a chance to take action.

It is important to note that Anadrol 50 does exhibit some tendency to convert to dihydrotestosterone, although this does not occur via the 5-alpha reductase enzyme (responsible for altering testosterone to form DHT). Anadrol 50 is already a dihydrotestosterone based steroid. Aside from the added c-17 alpha alkylation (discussed below), it differs from DHT only by the addition of a 2-hydroxymethylene group. This grouping can be removed metabolically however, reducing oxymetholone to the potent androgen 17alpha-methyl dihydrotestosterone (mestanolone; methyldihydrotestosterone). There is little doubt that this biotransformation contributes at some level to the androgenic nature of this steroid, especially when we note that in its initial state Anadrol 50 has a notably low affinity for the androgen receptor. While we have the option of using the reductase inhibitor finasteride (see: [email protected]) to reduce the androgenic nature of testosterone, it offers us no benefit with Anadrol 50 as this enzyme is not involved.

The principle drawback to Anadrol 50 is that it is a 17 alpha alkylated compound. Although this design gives it the ability to withstand oral administration, it can be very stressful to the liver. Anadrol [email protected] is particularly dubious because we require such a high milligram amount per dosage. The difference is great when comparing it to other oral steroids like Dianabol or Winstrol, which have the same chemical alteration. Since they have a slightly higher affinity for the androgen receptor, they are effective in much smaller doses (seen in the 5mg and 2mg tab strengths), Anadrol 50 has a lower affinity, which may be why we have a 50mg tablet dosage. For comparison taking three tablets of Anadrol 50 (150mg) is roughly the equivalent of 30 Dianabol tablets or 75 Winstrol tablets. When looking at the medical requirements, the recommended dosage for all ages has been 1 -5 mg/1 of body weight. This would give a 220 lb person a dosage as high as 10 Anadrol 50 tablets (500mg) per day.

When discontinuing Anadrol 50, the crash can be equally powerful. To begin with, the level of water retention will quickly diminish, dropping the user's body weight dramatically, this should be expected, and not of much concern. What is of great concern is restoring endogenous testosterone production. Anadrol 50 will quickly and effectively lower natural levels during a cycle, so HCG and/or Clomid/Nolvadex are a must when discontinuing a cycle. The common practice of slowly tapering off your pill dosage is wholly ineffective at raising testosterone level without ancillary drugs, a run away cortisol level will likely strip much of the muscle that was gained during cycle. If HCG and/or Clomid/Nolvadex are used properly, the person should be able to maintain a considerable amount of new muscle mass. Before going off, some alternately choose to first switch over to a milder injection like Deca-Durabolin. This is in an effort to harden up the new mass, and can prove to be an effective practice (Although a drop of weight due to water loss is likely when making the switch, the end result should be the retention of more (quality) muscle mass with a less pronounced crash, Remember ancillaries though, as testosterone production will not be rebounding during Deca therapy.
   
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