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Onxandrolone Study
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Onxandrolone Study - 03-04-2005, 04:45 AM

Study on the effects of oxandrolone.


Here is the abstract and link to full article.

http://jap.physiology.org/cgi/content/full/96/3/1055


We investigated the effects of the anabolic androgen, oxandrolone, on lean body mass (LBM), muscle size, fat, and maximum voluntary muscle strength, and we determined the durability of effects after treatment was stopped. Thirty-two healthy 60- to 87-yr-old men were ran***ized to receive 20 mg oxandrolone/day (n = 20) or placebo (n = 12) for 12 wk. Body composition [dual-energy X-ray absorptiometry (DEXA), magnetic resonance imaging, and (2)H(2)O dilution] and muscle strength [1 repetition maximum (1 RM)] were evaluated at baseline and after 12 wk of treatment; body composition (DEXA) and 1-RM strength were then assessed 12 wk after treatment was discontinued (week 24). At week 12, oxandrolone increased LBM by 3.0 +/- 1.5 kg (P < 0.001), total body water by 2.9 +/- 3.7 kg (P = 0.002), and proximal thigh muscle area by 12.4 +/- 8.4 cm(2) (P < 0.001); these increases were greater (P < 0.003) than in the placebo group. Oxandrolone increased 1-RM strength for leg press by 6.7 +/- 6.4% (P < 0.001), leg flexion by 7.0 +/- 7.8% (P < 0.001), chest press by 9.3 +/- 6.7% (P < 0.001), and latissimus pull-down exercises by 5.1 +/- 9.1% (P = 0.02); these increases were greater than placebo. Oxandrolone reduced total (-1.9 +/- 1.0 kg) and trunk fat (-1.3 +/- 0.6 kg; P < 0.001), and these decreases were greater (P < 0.001) than placebo. Twelve weeks after oxandrolone was discontinued (week 24), the increments in LBM and muscle strength were no longer different from baseline (P > 0.15). However, the decreases in total and trunk fat were sustained (-1.5 +/- 1.8, P = 0.001 and -1.0 +/- 1.1 kg, P < 0.001, respectively). Thus oxandrolone induced short-term improvements in LBM, muscle area, and strength, while reducing whole body and trunk adiposity. Anabolic improvements were lost 12 wk after discontinuing oxandrolone, whereas improvements in fat mass were largely sustained
   
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pincrusher
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03-04-2005, 09:27 AM

nice study but i attribute the loss of strength gains to their age. without having much natural testosterone in their system which they wouldnt have at the age levels used, you cant expect them to maintain strength gains. at least this is a possitive for those people who have always thought of anavar as a fat reducing product.

when will they do a study using healthy 25-35 yr old men so they have something more realistic for us all to compare with?
   
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03-04-2005, 02:02 PM

True pin -- it would be interesting to see where they received funding for the study. Despite all the rhetoric you hear about "objective research", quite often study initiators know the outcome they are looking for and will "stack the deck" to ensure an outcome they desire....

In other words, in this political climate who wants a study released extolling the values of steroids? Damn media....


If you think education is expensive try ignorance.
   
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04-06-2005, 03:12 PM

Just think what 50mg ed would have done!
   
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