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Lowering shbg
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Lowering shbg - 06-20-2013, 01:22 PM

I can confused about the effect of certain drugs (drostanelone/stanozolol/ proviron) on shbg. It keeps getting repeated that they all lower shbg, thereby increasing free test. But I have also read that they have a strog affinity to shbg, so wouldnt it stand to reason that they dont actually lower the amount of shbg, they just deflect shbg's effect on tesosterone? The mechanism of action proabaly doesnt matter much to most, but if that is true, it means that if perhaps stanozolol has a higher affintiy to shbg than drostanelone, stacking them together would greatly increase the effects of the drostanelone?

I have asked this question before with no replies, so if anyone has any ideas, even anecdotal, they are more than wlcome to chime in. Thanks!
   
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06-20-2013, 01:32 PM

I haven't read up on that in a while, but Winstrol does, indeed lower SGHB at a pretty low dose. Here is an article on that very thing. It is addressed about midway through the article....

Winstrol - Oral versus Injectable (More Different Than You Think!)
   
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06-21-2013, 06:11 PM

Proviron lowers SHBG and works about the same as Masteron. I wouldn't use either as an anabolic though.

17 methyl oral steroids lower SHBG because of their interaction with the liver (drostanolone is methylated at C-2). IIRC almost all SHBG is produced by the liver. It's not because orals deflect SHBG or something like that. 17-methyl steroids have unique properties. 17-methyls are also great for a quick strength boost.
   
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06-22-2013, 04:56 PM

Ahhhh thank you for the response. That makes more sense than what I was thinking.
   
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06-23-2013, 02:40 PM

Winny at 10mg a day knocks down shgb but proviron and mast are safer at higher doses so you can get the libido, hardness and strength from them longer without harm
   
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