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HCG Explained
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HCG Explained - 10-25-2013, 12:03 PM

Guys I don't know if this will help but I found this on the web, I personally use HCG 500ius 2x a week but could never find a good article about it. And I see HCG threads here so maybe this will help I liked it..perhaps this info is already on this board if it is...sorry if not..I hope it helps. BTW I did not write this, just passing on info


HCG-Human Chorionic Gonadatropin.

Hello and welcome to my thread on HCG which IMO is a very important part of most cycles and something which should be taken seriously and respected? So grab a drink, kick back, and get ready to read!

HCG is administered through the use of injections usually 1-3 times per week, and is used to reduce or prevent testicular atrophy and shutdown when on cycle. It is available on prescription and black market and commonly used for a lot of cycles as testicular support.
Below is a list of points and information on HCG and its usage. It also tells us how to administer it and how to prepare it for usage. This is a collection of posts from various boards that were collected and combined and have been taken by me, edited/changed and placed here for educational needs of the forum users here.

What is HCG?

HCG stands for Human Chorionic Gonadotropin.

Where does HCG come from?
It is extracted from the urine of pregnant women.

Is HCG a scheduled medication?
No, it's similar to clomid and Liquidex as far as US laws go. However you would need a prescription to purchase legally in the US.

What is HCG normally used for?
It is used to help females get pregnant, and can be used to stimulate testosterone production in males.

How does HCG work?
HCG mimics LH (leutenizing hormone). The presence of LH causes the Leydig cells in the gonads to produce testosterone. This effect also restores the size of the testes rather quickly if they were suppressed from a cycle.

What should HCG be used for?
HCG is commonly used by bodybuilders on either very heavy or very long cycles, when the HPTA gets severely suppressed. Although HCG can be used in almost any cycle, the benefits are most pronounced on heavy/long ones.

How do you take it?
You can take it IM or Sub-q.

Can I use HCG only for PCT?
No you shouldn't. It is better than nothing, but clomid or Nolva are far better plans. Since HCG mimics LH, your body won't begin producing its own LH, as it sees no need to because test levels are high. You stop the HCG, your balls stop making test until your body begins producing adequate levels of its own LH, and that may take a while if you don't use clomid or nolvadex to stimulate LH production. The use of clomid or Nolvadex should also be continued at least 2 weeks after HCG is discontinued to avoid the v causing problems.

Can I use HCG during cycle and when?
Yes you can, imo to best benefit from HCG is to run it by the last 3-4 weeks of your steroid cycle. Do not run HCG if you're getting signs of gyno, HCG will make it worst, so be careful.

What dose do you run HCG at?
HCG is best dosed at 500 IU and/or 1000iu, more than that can cause too much aromatization, and some people won't react to less than 500iu. So during the last 4 weeks of a cycle, you shoot 500 IU of HCG twice a week or 1000 IU once a week

Can HCG be used w/out steroids to boost test production above baseline?
Yes. It is not recommended however. Continued use of HCG will desensitize the leydig cells to LH, meaning once you stop using the HCG as an artificial LH, you will crash bad. The natural LH production once restored by using nolvadex or clomid, may not be as effective as it once was. To boost natural test above baseline, anastrozole, nolvadex and clomid are better choices.

How long does HCG boost testosterone for?
HCG can boost testosterone for up to 5 days following the last dose, although the drugs half-life is very short, and it's no longer active at that point.

Can HCG cause gyno?
Yes. Estrogen is elevated by two ways from HCG use. Primarily from the sharp rise in testosterone, this allows more testosterone to aromatize to estrogens. Secondly HCG can cause a small amount of estrogen to be produced which is not from the result of aromatizing, and this is the reason that a combination of an anti aromatize such as liquidex/arimidex/letrozole and a estrogen receptor blocker such as nolvadex are ideally used. The nolvadex may also offer some additional benefit to help avoid a negative estrogen feedback to the HPTA during HCG therapy, which would otherwise slightly lessen the effectiveness of the therapy.

How does HCG come packaged?
You get 2 vials or amps, 1 has the powdered HCG in it, and the other has a diluent in it(solvent). The diluent is typically bacteriostatic water, or sterile water w/ .09% sodium chloride. The package commonly comes w/ enough diluents to make concentrations ranging from 250-10,000 IU per ml.

If your package is 5000 IU, and you add 1ml diluents, you have 5000 IU per ml.
If you add 5ml diluents, you final mix is then 1000 IU per ml.
If you add 10ml diluents, then 500 IU per ml and so on.
This is simple math, and you don't want to screw it up, know what dose you are taking!

If your package doesn't include enough diluent to make the concentration you want, you have 2 options to make it easy to accurately measure your doses.

1-buy some insulin syringes, U-100 type. On the graduated markings, the 100 IU mark is equal to 1ml; the 50 IU is .5ml etc. THIS DOES NOT MEAN IF YOU FILL IT TO THE 100IU MARK THAT YOU ARE TAKING 100IU OF HCG! IU's are not a measurement of volume or weight; they are a measure of effectiveness for a desired response from specific drugs/compounds. Every compound is different. These are insulin syringes, and they are made for insulin-not HCG. Insulin is the same iu concentration per ml every time (if its u100 type), HCG is not.
Imagine if you made your HCG 10,000 IU per ml. if you fill the insulin syringe up to 100 IU mark, you now have 10,000 IU in there! Not good. You must understand this.
So if you had 5000 IU per ml, and wanted to take a 500 IU shot, you would inject 10 IU on the insulin syringe scale.

2-buy some bacteriostatic water off the internet, its easily found. Simply add more to dilute it to the desired concentration. Making lower concentrations are easier and more accurately dosed. Then it can accurately be measured w/ a regular syringe.

Mix the two together, they dissolve very easily. HCG can be very unstable and to make sure to not shake it and let it foam.... Be careful when reconstituting it. Be gentle and run the bac water down the side of the vial not allowing to foam up... Keep things sterile folks. Unused HCG can be refrigerated and is ok to use within 30 days after the initial mixing.

HCG Absorption
A detectable rise in HCG is seen in 2hr, peak levels in 6 hrs and remain at this level for 36 hr.
HCG levels begin to decline at 48h and approach baseline at 72h.
HCG Preparation & Usage:
This is how to properly prepare 5000 ius hcg for a ten week supply.
Hcg is a peptide. That means it is a large complex molecule, that is held together by very weak carbon bonds at points throughout its structure, and that means it is sensitive to shock, light , freezing, and heat.

It is therefore imperative that it is handled delicately throughout the preparation process, as well as after.
Before proceeding, pick a clean, dry, well lit work area, and sterilise as best you can. Also use laboratory gloves.

1) Purchase empty 10 ml vial, and 30mls bacwater
2) Crack both single use vials supplied with hcg kit
3) Using slin pin, draw up 1 ml supplied bacwater
4) SLOWLY run the 1ml bacwater down the side of the crack-top containing the lypholised hcg powder.
5) Allow to mix on its own
6) Add 9 mls bacwater to stoppered empty vial with IM pin "3x3ml's"
7) SLOWLY draw up the 1ml HCG solution
8) Insert loaded slin pin into 10ml vial containing bacwater.
9) Invert 10ml vial enough to submerge needle, and SLOWLY push the plunger.
10) SLOWLY pull plunger back out, and push in again, to "rinse".
11) Withdraw slin pin, and discard.
12) Refrigerate finished product.
You now have 10 mls HCG dosed at 500 iu/ml
Assuming you will be using 250 IU 2x weekly, that's a 10 week supply.

HCG is injected Sub-Cutaneously (below the skin) with an insulin needle(u-100).A u-1oo needle is designed specifically for insulin dosing. But for our purposes,- 1/2 the syringe-the hash mark designated 50 equals 1/2 ml which, assuming you followed the instructions above, equals 250 iu's
Once you've SLOWLY (remember, HCG is shock sensitive) drawn up the desired dose. Set the pin down with the needle hanging over the edge of whatever surface you are using. Find a spot on your legs or ab***en you can reach with both hands, and pinch up 1/2 inch of skin. Prepare site with alcohol. We'll use a spot 1 inch to the right of the navel. Assuming you are right handed, pinch the skin with your left hand. Re-swab the raised spot to the right of your fingers. Pick up the pin and stick it in. push the plunger. Withdraw and discard.

Calculating HCG:
There isn't a specific ratio of cc/ml to IU. It depends on how you mix it. It's quite simple. If you dilute 5,000 IUs HCG with 5ml (cc) solvent, the end result is 1,000 IUs per ml (cc). Divide the same 5,000 IUs with 10 ml (cc) and the end result is 500 IUs per ml (cc). Therefore, a large part depends on the concentration of HCG per ampoule or vial.

Risks and Warnings.

1stly HCG should never be run/used etc in the actual PCT period. You may blast it in a heavier dosage in the 2 weeks leading into pct. Or/and run smaller dosages twice a week while on cycle.

Not everyone knows the dangers of misusage with this drug, high dosage shots or prolonged usage can/may lead to a desensitization of leydig cells, making the recovery even more difficult and longer in duration, which will lead to a reduction in gains from your cycles. In serious cases there maybe some permanent damage to the users testicles.

Dosages.

Opinions on dosages and routines vary and like most things it’s a personal choice for each individual user. Prevention is better than a cure and if HCG has been used in low dosages on cycle and the testes have not shutdown a much lower dosage may be used before going into PCT, than someone who did not utilize it and was shutdown. This is a safer methodology as well and is it removes the need for blasting a huge dosage as starter to PCT (more risk in high dosages and long usage). I have included a link to a study/presentation by Dr Swale a TRT specialist and his recommendations when using HCG it isn’t Gospel but defiantly worth taking a look at:

Need To Build Muscle - BodyBuilding Forums

Usage summary.

I personally recommend the usage of HCG on cycle at 500ius twice a week (say Mon/Thurs) for stints of up to 6 weeks (usually 4 on 4 off). In these off weeks I would run a dosage of Hcgenerate and cycle between the two until pct starts. User may have a bigger blast of HCG before going into PCT if required. This to me is the safest and most productive method as it avoids any prolonged usage of either and will stop any desensitization taking place and any damage from occurring, whilst preventing testicular shut down on the users cycle.
Users may use HCG all the way through (many do) in this case two dosages a week would suffice of 500ius. If users do not want to take for longish durations they must ensure usage occurs in the latter part of the cycle leading into just before pct. E.g. 12 weeks, HCG wks 6-12 etc. HCG can cause desensitization and even damage users with prolonged usage and high dosages so individual thought and personal experience is a must when planning on such usage.
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Last edited by ken913; 10-25-2013 at 12:10 PM.
   
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10-25-2013, 01:00 PM

Thanks for taking up needed thread space Ken. Lol just kidding .. Its good to have this info up off and on .. So you see it says to take hcg "starting" at last few weeks of a cycle. Doing hcg while "on" seems like wasting of money..
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Last edited by Ironbuilt; 10-25-2013 at 01:03 PM.
   
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10-25-2013, 03:20 PM

Quote:
Originally Posted by Ironbuilt View Post
Thanks for taking up needed thread space Ken. Lol just kidding .. Its good to have this info up off and on .. So you see it says to take hcg "starting" at last few weeks of a cycle. Doing hcg while "on" seems like wasting of money..
I think it's a matter of opinion. I would much rather run hcg my whole cycle as appose to just the end. Everyone just need to figure out what works best for themselves
   
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10-25-2013, 08:13 PM

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Originally Posted by jim230027 View Post
I think it's a matter of opinion. I would much rather run hcg my whole cycle as appose to just the end. Everyone just need to figure out what works best for themselves
X 2... But being on TRT I need to use it year round to maintain testicular function.


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10-25-2013, 09:58 PM

I have been chemically castrated for YEARS
   
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10-25-2013, 10:29 PM

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Originally Posted by AtomAnt View Post
X 2... But being on TRT I need to use it year round to maintain testicular function.
You can pulse it 8 weeks on 8 weeks off to avoid some of the estrogen sides. That should be enough to keep your nuts plump.
   
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10-26-2013, 08:25 AM

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Originally Posted by butthole69 View Post
You can pulse it 8 weeks on 8 weeks off to avoid some of the estrogen sides. That should be enough to keep your nuts plump.
I suggest just managing your estrogen with an ai rather than pulsing. Running 200-250 iu 2xew is not going to risk desensitization
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10-26-2013, 12:12 PM

Quote:
Originally Posted by butthole69 View Post
You can pulse it 8 weeks on 8 weeks off to avoid some of the estrogen sides. That should be enough to keep your nuts plump.
Quote:
Originally Posted by jim230027 View Post
I suggest just managing your estrogen with an ai rather than pulsing. Running 200-250 iu 2xew is not going to risk desensitization
Jim is right... and considering i am monitored by a physician and get regular bloodwork, I know my estrogen is in check.

BTW, Jim, that is what my doc has me doing. 250iu/E3D with aromasin and 100mg test E every 5 days... Bloodwork is perfect.


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10-26-2013, 04:22 PM

Atom.... Hold on to that dr! Good dr's like that are few and far. Good to know that you have everything dialed in! My protocal is similar
   
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