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DNP and Insulin
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DNP and Insulin - 04-14-2005, 08:43 PM

DNP and Insulin Part 1
The perfect ďoffĒ cycle
by Jason Mueller

Iím sure by now that everyone is familiar with the use of insulin of bodybuilding circles. Without a doubt, insulin use is the greatest advance in the sport since GH in the early 80ís. I would say that the massive size increases you have seen in the sport over the past five years have been a direct result of insulin use, more so than anything else. Insulin can also kill you.

Most of you are probably aware of DNPís use in bodybuilding. For those of you who arenít familiar with DNP, which by the way stands for 2,4-Dinitrophenol, it is an unbelievable fat burning drug. If youíve ever wondered how a pro bodybuilder drops down from say, 280 to 225-230 in a very short period of time, itís probably because that particular individual is using DNP with a host of other drugs like thyroid, clenbuterol, etc. In fact, this bodybuilder might develop thyroid problems and balloon up and down in weight, even missing shows or looking horrible at others. Man, good thing this isnít a real person weíre talking about. Anyway, I digress. DNP is the greatest thing to come along in dieting since, well, I guess itís about the only good thing to come along that I can think of. And, DNP will kill you quicker than insulin.

Before we continue on, letís get real for a moment. Please do not use either insulin or DNP. Iím not joking that either of them can kill you, in fact the bottle of DNP Iím looking at right now lists the many horrible consequences of just touching the stuff. Be warned that you are taking your life in your hands by using either insulin or DNP. DNP is used in bug sprays for Christís sake. Now that I got that off my chest, we can continue.

Iím really not going to bore you with long and complicated explanations of how both DNP and insulin work in the body, but I do need to touch on the subject. Many of the articles written about DNP refer to itís abilities to block the actions of insulin. This is true only in a limited sense. Insulin is released by pancreatic beta cells in response to elevated ATP/ADP ratios. Briefly, when your blood sugar levels rise, your ATP/ADP levels become elevated, inhibiting ATP sensitive potassium ion channels (KATP), altering the membrane potential of the pancreatic cells and causing insulin release. The key point here is that insulin will not be released unless ATP levels within the cells increase. DNP interferes with the protein complex ATP synthase, which allows for the synthesis of ATP from ADP and Pi (inorganic phosphate). Since DNP interferes with a key step in ATP production, obviously ATP levels never elevate within any cell, including pancreatic beta cells. Hence, the feedback system through the KATP channels (at least in regards to insulin release), is disabled, and you effectively make yourself a diabetic while on DNP.

The primary action of insulin in the body is to drive glucose into muscle and liver cells (stored as glycogen) which is converted into ATP. ATP again? Since DNP reduces ATP production significantly, it again interferes with insulin by preventing a significant amount of the glucose that is pushed into cells by insulin from ever being used as energy (at least by the cell). So, what is happening to all of this energy that is being expended through the electron transport chain to turn ADP and Pi into ATP? Itís thrown off as heat, and lots of it. In fact, because the amount of heat produced is a direct correlation of how much DNP is consumed, taking too much DNP will cook you from the inside out. Let me repeat this. Taking too much DNP will fry you like an egg. It doesnít sound like a pleasant way to die, does it? DNP is not one of those, hey a little did me good, more will do me better kind of substances. A little will do you good and more will burn your ass up.

So, now we understand the ways in which DNP interferes with some of the actions of insulin. Another action of insulin (thank you God) is that it promotes transport of amino acids from the bloodstream into muscles and other cells. Insulin also increases the rate at which amino acids are incorporated into protein. Although DNP does block the release of insulin and prevents a key component of the electron transport chain (ATP synthase, remember?), it does nothing to prevent the aforementioned extremely anabolic affect of insulin. Therefore, when you use DNP, you should be administering insulin at the same time. The exogenous insulin will still work its anabolic magic while the DNP burns off reams of body fat through the resultant metabolic increase.

Many so called Gurus are recommending incorporating DNP as a component to any steroid cycle to ensure that weight gained is purely muscle and not fat. While this certainly works great on paper, application is a little different. I am a firm believer in training and eating to grow while on a heavy cycle (and what other kind is there?) Anyone who has any kind of contact with any professional bodybuilder in the off season will see that the chicken and rice thing has been thrown out of the window and that junk food rules the day. Their drug use is of such magnitude that eating clean would simply not supply the necessary calories for growth. Have you ever tried to consume 5000+ calories while on a low fat diet? Good luck. So, while they are certainly growing like a weed in the off season, they also tend to put on a bit of fat. Big deal. Iím going to let you in on a little secret. The only time those guys look like that is when they are on stage. Many people assume that the top guys are in shape all year round because they never see any pictures of them in the off season. And with good reason. Most (not all, but most) bodybuilders look like a chipmunk with a walnut in each cheek in the off season. These fellow tend to get a bit fat and bloated from their diets and heavy drug use. Now taking DNP while cycling will certainly help keep you leaner. It will also make you weaker, uncomfortable, and more quick to tire from a workout. Obviously not a good combination for consuming mass quantities while kicking ass in the gym is it? Therefore, we need a schedule for DNP administration. Iím a firm believer in down time from cycles (another article me thinks?), not because of receptor down regulation but from other factors. I propose a system where the athlete uses AS for 10 weeks, similar to the system advocated by Paul Borreson, followed by three weeks of down time. During this down time, 24 days actually, the athlete uses DNP in conjunction with insulin and T3, losing body fat while maintaining lean body mass. The dosing schedule would be as follows:

Last day of AS administration
Days 1-8 DNP with insulin and T3
Days 9-16 DNP is not used, insulin use continues, T3 continues for days 9-12
Days 17-24 DNP with insulin and T3
BACK ON THE JUICE!!

Psychologically this isnít the easiest system to use. Most guys who take AS never want to come off because they canít deal with the trauma of not feeling ďjuicedĒ. You know that feeling you have that if your car were flip over twenty times in a horrible flaming wreck it wouldnít matter because youíre on and you wouldnít get hurt. Thatís the feeling Iím referring to, the feeling that Iím strong, Iím invincible and on top of the world. However, are you taking gear to give yourself some false sense of security or because you want to take your body to previously unseen levels? Every person Iíve seen who takes time off between cycles (weíre talking three weeks here people) is healthier, bigger, and in better shape than those who donít. Additionally, by staying leaner in the off season, you have less fat to lose before a show, which will result is less muscle catabolism while dieting. I think weíll see the day soon where bodybuilders are staying much leaner in the off season by incorporating a system like the one Iíve described above, and getting on stage much bigger.


STEELADDICTION is presenting fictitious opinions and does in no way encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal conduct.
   
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04-14-2005, 08:48 PM

Intersting read Steel.


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