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Bodybuilding Drug Profiles—Anastrozole
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Bodybuilding Drug Profiles—Anastrozole - 09-11-2006, 02:01 AM

From today, I'd like to share a series of articles on bodybuilding drug profiles. I hope the information in these articles would be helpful to you.


Anastrozole (Arimidex®) is the aromatase inhibitor of choice. The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren®) and can achieve a high degree of estrogen blockade, much moreso than Cytadren®. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.

As an aromatase inhibitor, Arimidex's mechanism of action -- blocking conversion of aromatizable steroids to estrogen -- is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid®) or tamoxifen (Nolvadex®), which block estrogen receptors in some tissues, and activate estrogen receptors in others. During a cycle, if using Arimidex, there is generally no need to use Clomid as well, but (as mentioned in the section on Clomid) there may still be benefits to doing so.

Arimidex is quite expensive, costing approximately $9 per milligram. With moderate doses of testosterone 0.5 mg/day is usually sufficient and in some cases may be too much.


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