i started using DMSO back in the early 80's for healing connective tissue as that was it's big use back then. so i don't have a problem with it. so i am looking for a product that is already made up as i would prefer not to fabricate my own, i have done it in the past. and could again if i had to. i have found DMSO to be a little irritating to the skin at times etc. just looking for a no hassle transderam that is effective.