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Dapoxetine
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Arrow Dapoxetine - 04-02-2014, 11:28 PM

DAPOXETINE is known to help prevent premature ejaculation.


Dapoxetine for premature ejaculation.[/SIZE]

Journal
Drug Ther Bull. 2014 Mar;52(3):30-3. doi: 10.1136/dtb.2014.3.0240.

ABSTRACT
Premature ejaculation, also referred to as rapid or early ejaculation, is a poorly understood disorder with no single, widely-recognised, evidence-based definition. Studies based on patient self-reporting indicate that premature ejaculation is a common complaint with estimated prevalence ranging from 4%-39% of men in the general community.(1) However, a lack of an accurate validated definition has made comparison of the results of such studies difficult.(2) In addition, perception of normal ejaculatory latency varies by country and differs when assessed by the patient or their partner.(3) ▾Dapoxetine (Priligy-A. Menarini Farmaceutica Internazionale SRL), a short-acting selective serotonin reuptake inhibitor (SSRI) is the first drug to be licensed in the UK for on-demand management of diagnosed premature ejaculation.(4) In this article we review the evidence for dapoxetine and discuss some of the challenges associated with its introduction.


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04-03-2014, 12:04 AM

You utilize this marvelous fuck drug yet bro? I usually rely on substantial amounts of alcohol for marathon sex.lol. it would be nice not to hafta get wasted to bang for a long time...
   
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04-03-2014, 12:50 AM

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Originally Posted by MattG View Post
You utilize this marvelous fuck drug yet bro? I usually rely on substantial amounts of alcohol for marathon sex.lol. it would be nice not to hafta get wasted to bang for a long time...
I haven't been laid in what seems like a millineum. So, I'll definitely be needing it. Someone that used it said he fucked like a porn star on it but it gave him a hang over. He still said it was well worth it to tear up the pussy like Mandingo.


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04-03-2014, 01:03 AM

Last few months, I've been having the exact opposite problem. Can't get off during sex, and sometimes during masturbation, no matter what I try. Any drug that can help me get off? The g/f is starting to get tired of the 3 & 4 hour fuck sessions that don't end in a bang. She's getting all self-conscious, and thinking that it's her or I don't like fucking her anymore.


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04-03-2014, 01:05 AM

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Originally Posted by johnjuanb1 View Post
I haven't been laid in what seems like a millineum. So, I'll definitely be needing it. Someone that used it said he fucked like a porn star on it but it gave him a hang over. He still said it was well worth it to tear up the pussy like Mandingo.
Well shit, you are in vegas right now. Find a good looking whore and beat it up
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04-03-2014, 02:04 AM

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Originally Posted by Lil' Sully View Post
Last few months, I've been having the exact opposite problem. Can't get off during sex, and sometimes during masturbation, no matter what I try. Any drug that can help me get off? The g/f is starting to get tired of the 3 & 4 hour fuck sessions that don't end in a bang. She's getting all self-conscious, and thinking that it's her or I don't like fucking her anymore.
Yea how much tren are u taking add some masteron in there as well I like taking tren ace mast e and test prop. I've been through the same exact problem and a few guys told me to run mast and boom. Idk if the peptide world has anything like that but it really turned around our relationship.
   
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04-03-2014, 04:48 AM

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Originally Posted by Lil' Sully View Post
Last few months, I've been having the exact opposite problem. Can't get off during sex, and sometimes during masturbation, no matter what I try. Any drug that can help me get off? The g/f is starting to get tired of the 3 & 4 hour fuck sessions that don't end in a bang. She's getting all self-conscious, and thinking that it's her or I don't like fucking her anymore.
Bet u are on tren and the prosser is dry like a saudi arabian well .. caber or prami plus some good diet helps .. Hide a turkey baster full of tapioca pudding next to the night stand and when she is barking to slam the screen door give her the pudding brutha..I use hot yogurt keeps her skinny..
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04-03-2014, 10:46 AM

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Bet u are on tren and the prosser is dry like a saudi arabian well .. caber or prami plus some good diet helps .. Hide a turkey baster full of tapioca pudding next to the night stand and when she is barking to slam the screen door give her the pudding brutha..I use hot yogurt keeps her skinny..
Where in the fuck do u come up with some of this shit lmfao
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04-03-2014, 11:47 AM

My dad told me a funny story. Our next door neighbor while I was a child used to keep a hot dog against his leg while he had sex with his wife. It stayed warm since it was against his leg. When he would run out of energy during sex with his wife he would pop the hot dog in and she wouldn't realize it and would keep going for while totally clueless. Hahahahaha
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04-03-2014, 01:49 PM

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Originally Posted by johnjuanb1 View Post
My dad told me a funny story. Our next door neighbor while I was a child used to keep a hot dog against his leg while he had sex with his wife. It stayed warm since it was against his leg. When he would run out of energy during sex with his wife he would pop the hot dog in and she wouldn't realize it and would keep going for while totally clueless. Hahahahaha
Bwahahaha! Thats ridiculous, never heard of such a thing. How the hell wouldnt she be able to tell the diference?lol
   
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04-03-2014, 02:18 PM

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Bwahahaha! Thats ridiculous, never heard of such a thing. How the hell wouldnt she be able to tell the diference?lol
Hahahaha maybe he had a small ding dong
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05-08-2014, 11:58 AM

This study show it's safe to stack dapoxetine with tadalafil or sildenafil.

Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.

AuthorsDresser MJ, et al. Show all Journal
Int J Impot Res. 2006 Jan-Feb;18(1):104-10.

Affiliation
Abstract
Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the phosphodiesterase-5 inhibitors tadalafil and sildenafil, agents used in the treatment of erectile dysfunction (ED), were investigated in an open-label, ran***ized, crossover study (n=24 men) comparing dapoxetine 60 mg, dapoxetine 60 mg+tadalafil 20 mg, and dapoxetine 60 mg+sildenafil 100 mg. Plasma concentrations of dapoxetine, tadalafil, and sildenafil were determined by liquid chromatography-tandem mass spectrometry. Tadalafil did not affect the pharmacokinetics of dapoxetine, whereas sildenafil increased the dapoxetine AUCinf by 22%; these effects were deemed not clinically important. Dapoxetine did not appear to affect the pharmacokinetics of tadalafil or sildenafil. Most adverse events were mild in nature. Thus, dapoxetine has no clinically important pharmacokinetic interactions with tadalafil or sildenafil, and the combinations are well tolerated.

PMID 16307008 [PubMed - indexed for MEDLINE]


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05-09-2014, 09:17 PM

Dapoxetine lengthened normal ejaculation time by about 300% at a dose of 30mg taken one hour before intercourse, and about 400% at a dose of 60mg.


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A benefit-risk assessment of dapoxetine in the treatment of premature ejaculation.

AuthorsHutchinson K, et al. Show all Journal
Drug Saf. 2012 May 1;35(5):359-72. doi: 10.2165/11598150-000000000-00000.

Affiliation
Abstract
Premature ejaculation (PE) is considered to be the most common sexual problem affecting men, despite the likelihood that it is under-diagnosed. It is a complex condition with many physical and psychological components, making management complicated. It is important to develop treatments for PE as it adversely affects quality of life for individuals and partners. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that has been developed principally for the treatment of PE. It is considered more suitable for the treatment of PE than other SSRIs as it can be used as an 'on demand' treatment to be taken a few hours before an expected sexual encounter, reducing the possibility of adverse effects. Dapoxetine may represent a breakthrough in the treatment of PE as it is the first drug to be licensed for this indication. This review attempts to present a balanced benefit-risk assessment of dapoxetine by examining the evidence from phase III clinical trials, focusing on its efficacy in prolonging intravaginal ejaculatory latency time (IELT), patient sexual satisfaction and safety in patients with PE. The benefits and risks of other therapies that are used to treat PE off-licence are also reviewed. There has only been one study to date that directly compares dapoxetine to another therapy, paroxetine, for this indication. It was found that dapoxetine is most effective at a dose of 60 mg in increasing IELT compared with placebo. All studies have also found that dapoxetine is well tolerated as an 'on-demand' therapy and with continual dosing; however, there are little data regarding possible long-term adverse effects. Findings of the dapoxetine development programme demonstrated that dapoxetine is associated with vasovagal-mediated (neurocardiogenic) syncope. No other associated significant cardiovascular adverse events were identified. Further research is needed to directly compare dapoxetine with other therapies and to investigate the outcomes of dapoxetine used in conjunction with behavioural therapies, and other non-pharmaceutical therapies.


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05-12-2014, 10:28 PM

Dapoxetine appears to improve personal distress and interpersonal difficulties associated with premature ejaculation


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05-18-2014, 07:36 PM

An overview of pharmacotherapy in premature ejaculation.

Authors
Porst H.
Journal
J Sex Med. 2011 Oct;8 Suppl 4:335-41. doi: 10.1111/j.1743-6109.2011.02451.x.

Affiliation
Abstract
INTRODUCTION: With increasing interest and clinical research in male sexual disorders, it has become clear that not only psychological but also organic, neurobiological, and genetic factors may play an important role in premature ejaculation (PE).

AIM: This article provides an overview of the different treatment options both for lifelong (primary, "congenital") and acquired (secondary) PE.

METHODS: Review of the literature.

MAIN OUTCOME MEASURES: Currently used treatment options for PE.

RESULTS: Treatments reviewed include psychological/behavioral/sexual counseling therapy, topical anesthetics, dapoxetine, and other selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and phosphodiesterase-5 (PDE-5) inhibitors.

CONCLUSIONS: Before starting any therapy for PE, correct diagnosis has to be made considering the patient's reported intravaginal ejaculatory latency time (IELT) and the duration and type of PE. Concomitant erectile dysfunction (ED) should be either ruled out or proven by appropriate means. In uncomplicated cases of PE with stable partnerships, medical treatment represents the first-choice option with a high likelihood of success. Dapoxetine, where available, or other SSRIs provide suitable therapeutic options with a good risk/benefit profile for patients. In complicated ("difficult-to-treat") PE patients, a combination of medication and sexual counseling should be considered the first treatment option. Combination therapies of PDE-5 inhibitors and PE-related medications should be offered to patients suffering from comorbid PE and ED, with ED treatment starting first. In those patients with severe PE-IELTs of <30-60 seconds or anteportal ejaculation-combination therapy of topical and oral medications can be offered and may considerably increase IELT, compared with either monotherapy.


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05-21-2014, 10:25 AM

Post from another forum....

"I've used this a few times, if you need to absolutely punish her, dapox is perfect!"


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05-22-2014, 07:00 PM

Here is a post from a SuperiorPeptide customer at another forum:

"Used it last night and all I can say it wow. The stuff definitely works. Made me last a hell of a lot longer than I thought it would, which helped with confidence. Went at it a couple times last night and a couple times this morning. All I did was take one dose of 30mg then 5mg about 5 hours later, don't know why. I felt like it even worked this morning, either that, just the confidence boost itself helped that much. Great product!"


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05-22-2014, 11:57 PM

Post from another forum on dapoxetine...

"just tried some dapoxetine for first time last night. It's a research chem that is being tested as a treatment for PE and it's been tested mostly on guys who can't last longer than 2 minutes before losing it. I've never really had an issue with not lasting long enough but I've had to use stop-start sometimes to keep it together which sometimes isn't the best.

I took a 60 mg dose at 8:30 last night and around 10:00 got started. We spent a good 20 minutes with her grinding on top however she wanted and I had zero urge to blast. She ended up with a charlie horse in her hamstring mid small orgasm and had to stop and recuperate and she thought that was the end of it.

We started again about 30 minutes later and once again, about 20 minutes of her riding and grinding to the hilt, about a 5 minute oral session, then another 10 minutes or so back to the riding until she finally collapsed in a ball drenching heap. As soon as she was obviously done I just pumped hard and deep about a minute and finished myself.

I actually suggested she settle down for a second when she started clawing me to make her last longer but she may have been too far gone already because she just said f it and went for it.

This stuff is great for guys with normal control abilities. The studies say it helped guys with severe PE issues get from 2 minutes to 3.5 minuts but if you're a normal guy who can control himself using other techniques this chem gives me ABSOLUTE COMPLETE MENTAL CONTROL
oer the matter. You won't cum until you are ready no matter how furious you are going at it or for how long. Give this stuff a try: 30-60 mg 2 hours before getting active."


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