AnaSCI - Fitness Evolved

Buy Needles and Syringes with NO PRESCRIPTION   Synthetek Muscle Building And Fat Loss Products   Cheap Pure Supplements

©ALL CONTENT OF THIS WEBSITE IS COPYRIGHTED AND CANNOT BE REPRODUCED WITHOUT THE ADMINISTRATORS CONSENT 2003-2019

   
  Synthetek Syntherol  
   
   
   
Largest Selection of Bodybuilding Products   Largest Selection of Bodybuilding Products   Largest Selection of Bodybuilding Products


User CP FAQ Members List Calendar New Posts Quick Links Log Out

AnaSCI Fitness Evolved  AnaSCI Fitness Evolved  AnaSCI Fitness Evolved  AnaSCI Fitness Evolved  AnaSCI Fitness Evolved


        
        
        
        
        

Automatic Translations (Powered by Yandex):
Albanian Belarusian Catalan Czech Danish Dutch English Estonian Finnish French German Greek Hungarian Italian Latvian Lithuanian Macedonian Norwegian Portuguese Russian Slovak Slovenian Spanish Swedish Turkish Ukrainian

Go Back   Anabolic Steroids Discussion and Bodybuilding Forum > Peptides & Growth Forum > Peptides & Human Growth Factors

Like Tree6Likes
  • 1 Post By johnjuanb1
  • 1 Post By johnjuanb1
  • 1 Post By johnjuanb1
  • 1 Post By johnjuanb1
  • 1 Post By 101st Ranger
  • 1 Post By johnjuanb1

Reply
 
LinkBack Thread Tools Display Modes
RAD140 - New SARM
Old
  (#1)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
RAD140 - New SARM - 01-19-2016, 11:31 PM

I paraphrased this study.

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140

The stability of RAD140 was high (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes, and it also had good bioavailability in rats (F = 27−63%) and monkeys (65−75%). (This shows high oral bioavailability in primates.)

RAD140 demonstrated excellent affinity for the androgen receptor (Ki = 7 nM vs 29 nM for testosterone and 10 nM for DHT) as well as good selectivity over other steroid hormone nuclear receptors, with the closest off target receptor being the progesterone receptor

RAD140 increased the weight of the levator ani muscle above that of the intact control starting with the lowest tested dose (0.1mg/kg). (RAD140 builds muscle at dosing of 10mg in a 220Lb "animal")

Interestingly, RAD140 demonstrated no stimulation of the prostate above the intact animal control level until the highest dose tested, 30 mg/kg.
At 0.3 mg/kg, RAD140 demonstrated muscle efficacy similar to Testosterone Propionate at 0.5 mg/kg. (I interpret this to mean 30mg RAD140 per day builds muscle as effectively as 50mg Testosterone Propionate per day in a 220Lb "animal")

MONKEY DOSING INFO

The results on animal body weight of 28-day dosing with RAD140 at 0.01 mg/kg.
In this study, a mean weight gain of greater than 10% in just 28 days of dosing was achieved at a dose of just 0.1 mg/kg [color="red"]( These monkeys gained 10% muscle in 28 days with the equivalent dose of 10mg per day in a 220Lbs "monkey". That means if you weigh 220Lbs, you would gain 22Lbs of lean muscle in 28 days at 10mg/day, if you respond like a monkey!) [color="red"]
Muscle showed a qualitative trend that increases with dose. Although[b] it appears that the majority of mass increase was due to lean mass increase.
Despite the rather dramatic increases in body weight over such a short time, there was no elevation of liver enzyme transaminase levels in any animal at any dose >2 fold over its baseline value. Given the well-established relationship between oral androgen use and liver stress indicators, we were quite pleased that at a dose 10-fold greater than the fully effective dose we saw minimal liver enzyme elevations.

RAD140 is potency selective, since it stimulates muscle weight increases at a lower dose than that required to stimulate prostate weight increases. Moreover, it is also efficacy selective, because it is fully anabolic on muscle but demonstrates less than complete efficacy on the prostate and seminal vesicles and, in fact, can partially antagonize the stimulation of the seminal vesicles induced by testosterone. [color="red"](Taking RAD140 simultaneously with testosterone can lower some negative side effects from testosterone)[color="red"]
RAD140 has excellent pharmacokinetics and is a potent anabolic in nonhuman primates as well.
cybrsage likes this.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#2)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
01-20-2016, 01:26 PM

RAD140 Half-Life: approximately 48 hours.
cybrsage likes this.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#3)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
01-22-2016, 04:05 PM

right about RAD140 being a wet compound. In up 4Lbs in 3 days while on my damn near starvation diet. Feels like test cyp.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#4)
AnaSCI SENIOR
 
101st Ranger's Avatar
 
Offline
Posts: 626
Join Date: Aug 2013
Location: Maryland
01-25-2016, 03:54 PM

So, do I understand this to be relatively safe regarding prostate sides? That appears to be what I read, but want to make sure that is what you understood as well.

Thanks brother.
   
Reply With Quote
Old
  (#5)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
01-25-2016, 07:25 PM

Quote:
Originally Posted by 101st Ranger View Post
So, do I understand this to be relatively safe regarding prostate sides? That appears to be what I read, but want to make sure that is what you understood as well.

Thanks brother.
Yes, it not only is safe on the prostate, but it lessons the negative prostate effects from testosterone if you stack them together.
cybrsage likes this.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#6)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
01-25-2016, 07:25 PM

I don't notice lethargia from RAD140. I do however feel more agressive. I just weighed. Since adding RAD140 I've gone from 210 to 217Lbs. All I've had today are a dozen egg whites, 2 scoops of whey protein, 2 cups of steamed white rice, 1/2 cup oats, one cup and a half non fat milk, and a bowl of steamed broccoli, green beans, and spinach. That's around 1,000 calories. I expected to be 210 because I took clenbuterol twice today at 100mcg total. Plus ECA, Kratom, and all my other anabolics, peptides, HGH, Slin, YK11, mk677.
Basically, I was stabilized at 211 or so on all the same compounds, then added RAD and weight is coming on fast, just like it did in the 3 monkey studies.
cybrsage likes this.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#7)
AnaSCI VET
 
Offline
Posts: 4,234
Join Date: Aug 2005
Lightbulb 01-25-2016, 08:32 PM

Quote:
Originally Posted by johnjuanb1 View Post
Yes, it not only is safe on the prostate, but it lessons the negative prostate effects from testosterone if you stack them together.
That's an interesting positive effect.
   
Reply With Quote
Old
  (#8)
AnaSCI SENIOR
 
101st Ranger's Avatar
 
Offline
Posts: 626
Join Date: Aug 2013
Location: Maryland
01-25-2016, 08:33 PM

Quote:
Originally Posted by johnjuanb1 View Post
Yes, it not only is safe on the prostate, but it lessons the negative prostate effects from testosterone if you stack them together.
Awesome! Really appreciate that. Kinda just what I needed to hear. Hope you keep logging on this.
Jonny likes this.
   
Reply With Quote
Old
  (#9)
AnaSCI SENIOR
 
101st Ranger's Avatar
 
Offline
Posts: 626
Join Date: Aug 2013
Location: Maryland
01-25-2016, 08:44 PM

I'm also trying to fully understand the implication of:

"...with the closest off target receptor being the progesterone receptor".

Clearly my focus is on prostate sides. And I know you said that stacked w test, that there is a benefit to the test induced, or as it were, estro induced sides. BUT, I ask about the above text because I believe my prostate issues stem from DHT/progesterone.

Any insight into this?

Thanks brother!
   
Reply With Quote
Old
  (#10)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
01-26-2016, 08:00 PM

Quote:
Originally Posted by 101st Ranger View Post
I'm also trying to fully understand the implication of:

"...with the closest off target receptor being the progesterone receptor".

Clearly my focus is on prostate sides. And I know you said that stacked w test, that there is a benefit to the test induced, or as it were, estro induced sides. BUT, I ask about the above text because I believe my prostate issues stem from DHT/progesterone.

Any insight into this?

Thanks brother!
I'm not sure. I take a low dose of tadalifi daily to help with my prostate. I'm on DHT/progesterone detivatives all the time: right now test prop/tren/Masteron plus other things. Here is a study in tadalifil and the prostate:

lower urinary tract symptoms secondary to benign prostatic hyperplasia.
Ran***ized controlled trial
McVary KT, et al. J Urol. 2007.
Show full citation
Abstract
PURPOSE: We assessed the efficacy and safety of tadalafil dosed once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia.

MATERIALS AND METHODS: Following a 4-week, single-blind, placebo run-in 281 men were ran***ly assigned (1:1) to 5 mg tadalafil for 6 weeks, followed by dose escalation to 20 mg for 6 weeks or 12 weeks of placebo.

RESULTS: Tadalafil significantly improved the mean change from baseline in International Prostate Symptom Score at 6 weeks (5 mg tadalafil -2.8 vs placebo -1.2) and at 12 weeks (5/20 mg tadalafil -3.8 vs placebo -1.7). Larger changes were observed with inclusion of the placebo run-in at 12 weeks (5/20 mg tadalafil -7.1 vs placebo -4.5). Significant improvements were also seen in the International Prostate Symptom Score irritative and obstructive ***ains, the International Prostate Symptom Score quality of life index, a question about urinary symptom improvement and the Benign Prostatic Hyperplasia Impact Index (significant at 12 weeks) vs placebo. International Prostate Symptom Score and International Index of Erectile Function erectile function ***ain scores significantly improved in the 56% of men with lower urinary tract symptoms/benign prostatic hyperplasia who were sexually active and had erectile dysfunction. Changes in uroflowmetry parameters were similar in the placebo and tadalafil groups. Commonly reported (2% or greater) treatment emergent adverse events were "erection increased," dyspepsia, back pain, headache, nasopharyngitis and upper respiratory tract infection (each 5.1% or less). No change in post-void residual volume was seen with tadalafil treatment.

CONCLUSIONS: Tadalafil once daily was well tolerated and demonstrated clinically meaningful and statistically significant symptomatic improvement for lower urinary tract symptoms/benign prostatic hyperplasia. Tadalafil also improved erectile function in men with lower urinary tract symptoms and erectile dysfunction.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#11)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
01-26-2016, 08:04 PM

Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. - PubMed - NCBI

Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia.

There is no edit function here. This is the correct title of the study.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#12)
AnaSCI SENIOR
 
101st Ranger's Avatar
 
Offline
Posts: 626
Join Date: Aug 2013
Location: Maryland
01-26-2016, 09:04 PM

Yeah, I take it for mine as well. My urologist put me on it years ago. It certainly helps a bit.
   
Reply With Quote
Old
  (#13)
AnaSCI VET
 
johnjuanb1's Avatar
 
Online
Posts: 1,754
Join Date: Feb 2014
02-16-2016, 03:24 PM

RAD-140 is some very strong stuff!!! Elvia, Rambo, and I all noticed big time agression and rage plus being emotional. Weight gain comes very fast. I had a very hard time not losing my temper in crowds.
cybrsage likes this.


FLASH⚡️LABS
Make the world your bitch
with the best AAS and HGH!
PRICE LIST/ORDER EMAIL:
[email protected]

   
Reply With Quote
Old
  (#14)
Registered User
 
Barks's Avatar
 
Offline
Posts: 29
Join Date: Sep 2014
Location: Texas
03-27-2016, 12:50 PM

Can women run this sarm?
   
Reply With Quote
Old
  (#15)
Registered User
 
WesleyInman's Avatar
 
Online
Posts: 72
Join Date: Jul 2013
12-07-2016, 10:35 AM

RAD 140 really didn't do much for me. I didn't run it very long though either in fairness.

I did notice I sweat more when I used it, so I am sure I was leaning out a bit.

Another big thing I hear from users is mood enhancement. I never was fortunate enough to have that effect either.

But I do like the potential prostate protection it offers.


National Sponsored Strongman Competitor
   
Reply With Quote
Old
  (#16)
Registered User
 
cybrsage's Avatar
 
Online
Posts: 765
Join Date: May 2015
02-14-2017, 03:14 PM

Quote:
Originally Posted by Barks View Post
Can women run this sarm?
Yes, it does not have the same virilization side effects as testosterone itself has. Women get stronger results from it, so she should start low and ramp up.

If she is pregnant, breast feeding, or thinks she may be (or is trying to get) pregnant, she should not use any SARM or PED at all.
   
Reply With Quote
Old
  (#17)
AnaSCI VET
 
Offline
Posts: 1,740
Join Date: Feb 2007
10-09-2017, 08:51 PM

Has anyone used this recently?


"The foolish man thinks he will live for ever,
if he keeps away from fighting;
but old age won't grant him a truce
even if the spears do."
   
Reply With Quote
Old
  (#18)
Registered User
 
Online
Posts: 113
Join Date: Mar 2016
11-03-2017, 08:34 PM

Quote:
Originally Posted by odin View Post
Has anyone used this recently?
Wondering that myself.
   
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On



All times are GMT -4. The time now is 05:09 PM.



Content Relevant URLs by vBSEO 3.6.0
Copyright © 2003-2019 AnaSCI.org. All rights reserved.