AnaSCI - Fitness Evolved

Buy Needles and Syringes with NO PRESCRIPTION   Synthetek Muscle Building And Fat Loss Products   Cheap Pure Supplements

©ALL CONTENT OF THIS WEBSITE IS COPYRIGHTED AND CANNOT BE REPRODUCED WITHOUT THE ADMINISTRATORS CONSENT 2003-2019

   
  Synthetek Syntherol  
   
   
   
Largest Selection of Bodybuilding Products   Largest Selection of Bodybuilding Products   Largest Selection of Bodybuilding Products


User CP FAQ Members List Calendar New Posts Quick Links Log Out

AnaSCI Fitness Evolved  AnaSCI Fitness Evolved  AnaSCI Fitness Evolved  AnaSCI Fitness Evolved  AnaSCI Fitness Evolved


        
        
        
        
        

Automatic Translations (Powered by Yandex):
Albanian Belarusian Catalan Czech Danish Dutch English Estonian Finnish French German Greek Hungarian Italian Latvian Lithuanian Macedonian Norwegian Portuguese Russian Slovak Slovenian Spanish Swedish Turkish Ukrainian

Go Back   Anabolic Steroids Discussion and Bodybuilding Forum > Peptides & Growth Forum > Peptides & Human Growth Factors

Reply
 
LinkBack Thread Tools Display Modes
SR9009, What is it and what does it do?
Old
  (#1)
Registered User
 
cybrsage's Avatar
 
Online
Posts: 765
Join Date: May 2015
SR9009, What is it and what does it do? - 11-17-2017, 02:39 AM

SR9009 - a special SARM that does amazing things. I love reading PubMed, so that will be my major source of information about SR9009. Let's dive into it, shall we? When I have multiple quotes from one source, I will reference the source after the last quote.


Quote:
In addition to stimulating fatty acid metabolism in sedentary mice, PPARδ activation potently suppresses glucose catabolism and does so without affecting either muscle fiber type or mitochondrial content. By preserving systemic glucose levels, PPARδ acts to delay the onset of hypoglycemia and extends running time by ∼100 min in treated mice.
Obese mice using SR9009, kept on their high fat diet the entire time, saw a 60% GREATER weight loss than those who were not on it. The stress of being handled and such causes mice to greatly increase their metabolism and lose weight. Those with SR9009 lost a LOT more. This means SR9009 is great for fat loss.

Quote:
In addition to the decrease in fat mass we also observed a 12% decrease in plasma triglycerides (TGs) and a 47% decrease in plasma total cholesterol (Chol) (Fig. 5c). Plasma non-esterified fatty acids (NEFA) were also reduced (23%) along with plasma glucose (19%) in the SR9009 treated animals (Fig. 5c). There was also a trend toward a decrease in plasma insulin levels (35%). Consistent with the decrease in adipocity we also noted an 80% decrease in plasma leptin and a decrease (72%) in the proinflammatory cytokine IL-6 (Fig. 5d). Examination of plasma triglycerides and total cholesterol in lean mice also demonstrated the ability of SR9009 and SR9011 to reduce the levels of these lipids (Figs. 5e, 5f). Consistent with the decreased plasma TGs and total Chol we observed a significant decrease in the expression of genes encoding lipogenic enzymes (Fasn and Scd1) as well as cholesterologenic regulatory proteins (Hmgcr and Srebf2) with SR9009 treatment (Fig. 5g). In the WAT, SR9009 treatment resulted in a decrease in expression of genes encoding enzymes involved in TG synthesis (Fig. 5g) as was also observed in lean mice (Fig. 4d). Similar to our observations in lean mice (Fig. 4c), we observed that the REV-ERB agonist induced the expression of genes involved in fatty acid and glucose oxidation (Cpt1b, Ucp3, Ppargc1b, Pkm2 and Hk1) (Fig. 5g). Taken together with the results from the CLAMS experiments (Fig. 3), these data suggest that REV-ERB agonists increase energy expenditure by increasing fatty acid and glucose oxidation in the skeletal muscle. The gene expression data is also consistent with decreased TG synthesis in the liver and WAT as well as a reduction in hepatic cholesterol synthesis. We also examined the effects of SR9009 in a genetic model of obesity (ob/ob mice) and after 12-days of dosing we observed that SR9009 suppressed the degree of weight gain normally observed in this leptin deficient mouse with no significant alterations in glucose or insulin tolerance (Fig. 5h and data not shown).
https://openi.nlm.nih.gov/detailedre...363503f5&req=4


Other than fat percentage, what else went down? Well, just about everything bad did. Triglicerides dropped by 12%, Cholesterol dropped by 47%, blood sugar (glucose) dropped by 19%. Leptin dropped by 80% and cytokine (which helps cause inflammation) dropped by 72%. No change in glucose or insulin tolerance was seen, which is very important.


But what is this REV-ERB stuff you keep reading about? Well, basically, it controls metabolism and the circadian rhythm of your body. SR9009, through REV-ERB represses orexinergic gene expression. Why is this good?

Quote:
Given the intrinsic negative side effects associated with excessive motivation for food and lack of sleep, including anxiety, obesity, diabetes, and low self-esteem, our experiments suggest that the REV-ERB regulation of the orexin pathway may hold utility in ameliorating the detrimental effects of imbalanced circadian behavior via orexinergic pathways.
Wow, ok, orexinergic genes, when out of wack, cause overeating, insomnia, anxiety, obesity, diabetes, and low self esteem! What else does it do?

Quote:
Administration of the REV-ERB agonist, SR9009, at ZT0 (testing start time of zero) affects expression of orexinergic genes in the brain over a 24-hour period. We recently demonstrated that acute injections at ZT6, which corresponds to peak REV-ERB mRNA expression, results in increased wakefulness and locomotion. Orexin signaling via OX1R in the striatum and nucleus accumbens is associated with reward feeding and addictive behavior toward nicotine and other drugs [72–74]. In line with this, our lab recently demonstrated that administration of SR9009 injection decreased the addictive phenotypic properties of cocaine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786293/

SR9009 helps you feel more awake and you feel like moving around more. It also reduces the addictiveness of nicotine and cocaine (and other addictive drugs).



TL;DR
SR9009 greatly helps in reducing body fat, cholesterol level, triglicerides, and blood sugar. It helps you feel more awake and feel more like moving around and doing stuff. It reduces insomnia and binge eating, as well as the anxiety and low self esteem that come from those things. It really is a great SARM!
   
Reply With Quote
Old
  (#2)
AnaSCI VET
 
Offline
Posts: 2,397
Join Date: Feb 2012
Location: USA
11-18-2017, 02:05 AM

Very interesting. Thanks for posting.
   
Reply With Quote
Old
  (#3)
AnaSCI VET
 
Offline
Posts: 1,740
Join Date: Feb 2007
11-20-2017, 04:30 PM

Good info.


"The foolish man thinks he will live for ever,
if he keeps away from fighting;
but old age won't grant him a truce
even if the spears do."
   
Reply With Quote
Old
  (#4)
Registered User
 
Online
Posts: 71
Join Date: Sep 2017
11-21-2017, 02:56 PM

It is not a SARM since it does not interact with the androgen receptor at all. it is actually more similar to GW501516 in that it interacts with the PPAR delta. So I would speculate that it may have similar effects in terms of promoting cancer.
   
Reply With Quote
Old
  (#5)
Registered User
 
ketsugo's Avatar
 
Offline
Posts: 365
Join Date: Mar 2005
Location: Earth
05-01-2018, 12:57 PM

Quote:
Originally Posted by MyNameIsJeff View Post
It is not a SARM since it does not interact with the androgen receptor at all. it is actually more similar to GW501516 in that it interacts with the PPAR delta. So I would speculate that it may have similar effects in terms of promoting cancer.


True not considered a SARM but the cancer promoting theory is merely speculative weak and not valid
   
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On



All times are GMT -4. The time now is 07:04 PM.



Content Relevant URLs by vBSEO 3.6.0
Copyright © 2003-2019 AnaSCI.org. All rights reserved.