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Melanotan 2 for summer

Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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Someone mentioned to me about it making their flaccid penis bigger so I will put my reply in here... MT2 has been shown to increase erection ability and quality in numerous studies. By reason of the pathways it works within I would say a larger flaccid penis is highly probable. That's a common side effect with most drugs that help with erection (cialis etc). If it gives better erections it would make sense better blood flow etc so a bigger flaccid penis. Check the study below it gave 17/20 men with ED problems an erection with one dose (and no sexual stimulation)!

http://www.ncbi.nlm.nih.gov/pubmed/11035391
 
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Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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I have used superiors MT2 a few times at 100mcg and it is super strong. Even at that dose I get flushed and nauseous and I was taking another brand before this. I have got darker in the last few days but no sun exposure. I will let it build up for a few more days then go on a 6 min sunbed on the w/e :)
 

johnjuanb1

AnaSCI VET
Feb 17, 2014
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Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.

AuthorsWessells H, et al. Show all Journal
Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9.

Affiliation
Abstract
We review our experience with Melanotan II, a non-selective melanocortin receptor agonist, in human subjects with erectile dysfunction (ED). Melanotan II was administered to 20 men with psychogenic and organic ED using a double-blind placebo-controlled crossover design. Penile rigidity was monitored for 6 h using RigiScan. Level of sexual desire and side effects were reported with a questionnaire. In the absence of sexual stimulation, Melanotan II led to penile erection in 17 of 20 men. Subjects experienced a mean of 41 min Rigiscan tip rigidity>80%. Increased sexual desire was reported after 13/19 (68%) doses of Melanotan II vs 4/21 (19%) of placebo (P<0.01). Nausea and yawning were frequently reported side effects due to Melanotan II; at a dose of 0.025 mg/kg, 12.9% of subjects had severe nausea. We conclude that Melanotan II is a potent initiator of penile erection in men with erectile dysfunction. Our findings warrant further investigation of melanocortin agonists and antagonists on penile erection. International Journal of Impotence Research (2000) 12, Suppl 4, S74-S79.

PMID 11035391 [PubMed - indexed for MEDLINE]
 

Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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38
How many ml bacteriostatic water do you mix in the vial? 3?

I have just answered this in your log. But for anyone else I will copy and paste what I wrote in your thread :)

I see you have already mixed it. For future ref I recommend the 10mg MT2 to be mixed with 3ml bac water. So 1ml = 3.33mg. 0.1ml = 333mcg. I would start on about 2-3 ticks so pretty much 67-100mcg. No more than 333mcg would ever be needed even after weeks. I get really dark at about 200mcg.
 

johnjuanb1

AnaSCI VET
Feb 17, 2014
2,168
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Melanotan II and fat loss from thermogenesis.

Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression.

AuthorsLi G, et al. Show all Journal
J Endocrinol. 2004 Jul;182(1):123-32.

Affiliation
Abstract
The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats. Six-day central infusion of MTII (1 nmol/day) reduced body weight and visceral adiposity compared with ad libitum-fed control and pair-fed groups and markedly suppressed caloric intake in both CH and DIO rats. The anorexic response to MTII was similar in DIO relative to CH rats. MTII induced a sustained increase in oxygen consumption in DIO but a delayed response in CH rats. In both diet groups, MTII reduced serum insulin and cholesterol levels compared with controls. HF feeding increased brown adipose tissue (BAT) uncoupling protein 1 (UCP1) by over twofold, and UCP1 levels were further elevated in MTII-treated CH and DIO rats. MTII lowered acetyl-CoA carboxylase expression and prevented the reduction in muscle-type carnitine palmitoyltransferase I mRNA by pair-feeding in the muscle of DIO rats. Compared with CH controls, hypothalamic MC3 and MC4 receptor expression levels were reduced in DIO controls. This study has demonstrated that, despite reduced hypothalamic MC3/MC4 receptor expression, anorexic and thermogenic responses to MTII are unabated with an initial augmentation of energy expenditure in DIO versus CH rats. The HF-induced up-regulation of UCP1 in BAT may contribute to the immediate increase in MTII-stimulated thermogenesis in DIO rats. MTII also increased fat catabolism in the muscle of DIO rats and improved glucose and cholesterol metabolism in both groups.
 

johnjuanb1

AnaSCI VET
Feb 17, 2014
2,168
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36
Melanotan II Protects the Heart.

MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct.


AuthorsGetting SJ, et al. Show all Journal
J Leukoc Biol. 2004 Oct;76(4):845-53. Epub 2004 Jul 26.

Affiliation
Abstract
Investigation of the mechanisms activated by endogenous inhibitory pathways can lead to identification of novel targets for cardiovascular inflammatory pathologies. Here we exploited the potential protective role that melanocortin receptor type 3 (MC3-R) activation might play in a myocardial ischemia-reperfusion injury model. In resting conditions, mouse and rat heart extracts expressed MC3-R mRNA and protein, without changes following ischemia-reperfusion. At the cellular level heart macrophages, but not fibroblasts or cardiomyocytes, expressed this receptor, as demonstrated by immunogold labeling. In vivo, administration of the melanocortin agonist MTII (10 microg per mouse equivalent to 9.3 nmol) 30 min prior to ischemia (25 min) attenuated mouse heart 2 h reperfusion injury by approximately 40%, an effect prevented by the mixed MC3/4-R antagonist SHU9119 but not by the selective MC4-R antagonist HS204. Similar results were obtained when the compound was given at the beginning of the reperfusion period. Importantly, delayed myocardial damage as measured 24 h post-reperfusion was equally protected by administration of 10 microg MTII. The focus on MC3-R was also substantiated by analysis of the recessive yellow (e/e) mouse, bearing a mutated (inactive) MC1-R, in which MTII was fully protective. Myocardial protection was associated with reduced markers of systemic and local inflammation, including cytokine contents (interleukin-1 and KC) and myeloperoxidase activity. In conclusion, this study has highlighted a previously unrecognized protective role for MC3-R activation on acute and delayed heart reperfusion injury. These data may open new avenues for therapeutic intervention against heart and possibly other organ ischemia-reperfusion injury.
 

Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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I have upped over the last few days and gonna do about 300mcg pre bed now :)
 

Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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38
Superior's MT2 is potent. I haven't been on a sunbed since last week. This week I missed shots on 2 days. But been upping my dose to about 300mcg. Last night I took 300mcg and I flushed so bad... this is when I know it is top stuff. I get a lot of comments in work but today many kept saying I am getting darker everyday and basically look black. My beard has gone dark too so another bonus.
 

johnjuanb1

AnaSCI VET
Feb 17, 2014
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Perfect for precontest dieting


Melanocortinergic activation by melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat.

AuthorsGlavas MM, et al. Show all Journal
Endocrinology. 2007 Jul;148(7):3279-87. Epub 2007 Apr 5.

Affiliation
Abstract
The hypothalamic neurocircuitry that regulates energy homeostasis in adult rats is not fully developed until the third postnatal week. In particular, fibers from the hypothalamic arcuate nucleus, including both neuropeptide Y (NPY) and alpha-MSH fibers, do not begin to innervate downstream hypothalamic targets until the second postnatal week. However, alpha-MSH fibers from the brainstem and melanocortin receptors are present in the hypothalamus at birth. The present study investigated the melanocortin system in the early postnatal period by examining effects of the melanocortin receptor agonist melanotan II (MTII) on body weight, energy expenditure, and hypothalamic NPY expression. Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h. Stomach weight and brown adipose tissue uncoupling protein 1 mRNA were determined. In addition, we assessed central c-Fos activation 90 min after MTII administration and hypothalamic NPY mRNA after twice daily MTII administration from P5-P10 or P10-P15. MTII induced hypothalamic c-Fos activation as well as attenuating body weight gain in rat pups. Stomach weight was significantly decreased and uncoupling protein 1 mRNA was increased at all ages, indicating decreased food intake and increased energy expenditure, respectively. However, MTII had no effect on NPY mRNA levels in any hypothalamic region. These findings demonstrate that MTII can inhibit food intake and stimulate energy expenditure before the full development of hypothalamic feeding neurocircuitry. These effects do not appear to be mediated by changes in NPY expression.
 

Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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If guys wants the full fatloss/contest prep assistance from mt2 you are best taking it in the morning. This primarily as it will suppress your appetite and make dieting a lot easier :)


Perfect for precontest dieting


Melanocortinergic activation by melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat.

AuthorsGlavas MM, et al. Show all Journal
Endocrinology. 2007 Jul;148(7):3279-87. Epub 2007 Apr 5.

Affiliation
Abstract
The hypothalamic neurocircuitry that regulates energy homeostasis in adult rats is not fully developed until the third postnatal week. In particular, fibers from the hypothalamic arcuate nucleus, including both neuropeptide Y (NPY) and alpha-MSH fibers, do not begin to innervate downstream hypothalamic targets until the second postnatal week. However, alpha-MSH fibers from the brainstem and melanocortin receptors are present in the hypothalamus at birth. The present study investigated the melanocortin system in the early postnatal period by examining effects of the melanocortin receptor agonist melanotan II (MTII) on body weight, energy expenditure, and hypothalamic NPY expression. Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h. Stomach weight and brown adipose tissue uncoupling protein 1 mRNA were determined. In addition, we assessed central c-Fos activation 90 min after MTII administration and hypothalamic NPY mRNA after twice daily MTII administration from P5-P10 or P10-P15. MTII induced hypothalamic c-Fos activation as well as attenuating body weight gain in rat pups. Stomach weight was significantly decreased and uncoupling protein 1 mRNA was increased at all ages, indicating decreased food intake and increased energy expenditure, respectively. However, MTII had no effect on NPY mRNA levels in any hypothalamic region. These findings demonstrate that MTII can inhibit food intake and stimulate energy expenditure before the full development of hypothalamic feeding neurocircuitry. These effects do not appear to be mediated by changes in NPY expression.
 

Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
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38
I seem to be getting darker and I have had next to no sun for well over a week. It's getting hot over here so gonna spend the w/e in the sun so I should get really dark :)
 

Ironbuilt

Banned
Nov 11, 2012
8,353
0
0
Mûnich , Germany
Dark hair people do really well and I love it but to me less side like freckles appear if you have uva light. .. pic before and after LC.. see if you turn like her ?
 

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Elvia1023

AnaSCI VET / Donating Member
Oct 28, 2007
5,817
14
38
Dark hair people do really well and I love it but to me less side like freckles appear if you have uva light. .. pic before and after LC.. see if you turn like her ?

HAHA

That's the equivalent of using Greg Valentino and the other oil/implant guys for syntherol and aas users.

She must be on about 10mg per day and 4 hours on a sun bed :eek: That pic alone shows it's power :D

I am dark haired but I know many who are ligher haired and do great on MT2. I have to say Barbie looks fantastic with her MT2 tan too :love1: