I hope this helps. But don't go over the dose given here. Caffeine in large doses throws the endocrine system into overdrive which will counteract any synergistic effects. The body tries to prevent fat breakdown via the negative feedback loop. One way it does this with Anavar is to try and prevent the accumulation of cAMP within cells. Caffeine can be used to prevent this by inhibiting phosphodiesterases within the cell. It also can prevent the actions of adenosine, which make it very useful when used along side Anavar at a dose of 60mg-90 mg, pre workout. Good luck.