I know you and I share some common problems, but I can definitely tell a difference. It was very apparent when I did a Syntherol run as well. For me its almost like a foreign object in there and the more I aggravate it, ie lifting, the more PIP I get. I talked to my urologist about this and he said people with dense muscles are more likely to experience PIP. He said he had several older men that preferred single 500mg monthly injections and none of them experienced PIP as their bodies absorbed it more rapidly through the looser muscle tissue. If this is the case, I can see why lifting would aggravate for some of us.