The thing the studies don't cover to is the rest of the people in thems life most of the time......any one medication can be a benefit or a curse....a good example is these old farmers who chew ,drink, smoke ect and they live healthy lives until there 80 to 100 plus then you take some couch potato that eats a shit diet and lays on his ass all the time when he's not working if he even has a physical job of any type that dies in his late 30s of heart problems.....the difference these old farmers ate real food and meat diets and they never stopped working ,they kept there body needing to get up the next day and go again and your body adapts to that properly..... my point here trt isn't going to determine if you get heart problems I don't care what any bias study says.....trt ,your diet, your level of activity and just how you live your life is going to be what determines your out come in anything you do