bigdawg said:
I wanted to run igf-lr3 because i see no reason not to run it. I planned on doing 80mcg daily IM directly into the places i wanted improvement as this, from another thread i posted, seems to be the best way to use it. It has a systemic effect but the immediate injection spot will utilize it amount fully, the rest of the body will get trickle down effect. I planned on injecting Post Workout.
I think i wanted to run the anavar for my first cycle as it is a "milder" aas and just to see how i react to it before i try large stacks.
I will start a new thread with the specifics of what i want to run and what i am trying to achieve here in a few moments, any input would be greatly appreciated.
I would think that running AAS like Prop or even adding Turinabol would net you much better results. IGF-1 Lr3 tends to recently be ran only post-workout to stimulant localized growth without the dreaded intestinal growth so common with it's use more so than GH, it's the effect of IGF-1 on the intestines, as the receptors are highly concentrated there, that causes the "GH Gut." It also accerates the development of cancer cells more so than muscle cells, but I suppose it would only be a problem if you had cancer cells to begin with, but still. I have no personal experience with IGF-1, only studies and a national level competitive bodybuilder friend who says it's a waste of money as far as effectiveness goes unless one is on an elite level, he vouches for an increase in fat loss though, but again not even close to the level of other drugs.
Not really trying to talk you out of it, just make sure that you are aware and not jaded by it's claims. I personally might try it PCT post-workout into the trained muscles, but right now haven't ever tried it.
Here's a few studies for you, good luck with whatever you decide to do, and I hope you reach your goals.
"Insulin-like growth factor 1 (IGF-1) plays an important role in the regulation of intestinal growth and maturation, whereas the direct effects of growth hormone (GH) on intestinal growth are less clear. In this study the authors utilize a transgenic mouse model to assess the extent to which longterm excess of IGF-1 in a background of GH deficiency stimulates small bowel growth."
Journal of Parenteral and Enteral Nutrition, May/Jun 1997
"IGF-1 or insulin-like growth factor 1 is an important hormone that is produced in the liver and body tissues. It is a polypeptide and consists of 70 amino acids linked together. All mammals produce IGF-1 molecules very similar in structure and human and bovine IGF-1 are completely identical. IGF-1 acquired its name because it has insulin-like activity in fat (adipose) tissue and has a structure that is very similar to that of proinsulin. The body's production of IGF-1 is regulated by the human growth hormone and peaks at puberty. IGF-1 production declines with age and is only about half the adult value at the age of 70 years. IGF-1 is a very powerful hormone that has profound effects even though its concentration in the blood serum is only about 200 ng/mL or 0.2 millionth of a gram per milliliter (1-4).
IGF-1 and cancer
IGF-1 is known to stimulate the growth of both normal and cancerous cells(2,5). In 1990 researchers at Stanford University reported that IGF-1 promotes the growth of prostate cells(2). This was followed by the discovery that IGF-1 accelerates the growth of breast cancer cells(6-8). In 1995 researchers at the National Institutes of Health reported that IGF-1 plays a central role in the progression of many childhood cancers and in the growth of tumours in breast cancer, small cell lung cancer, melanoma, and cancers of the pancreas and prostate(9). In September 1997 an international team of researchers reported the first epidemiological evidence that high IGF-1 concentrations are closely linked to an increased risk of prostate cancer(10). Other researchers provided evidence of IGF-1's link to breast and colon cancers(10,11)."
Health News. Issue 76, April 1998
In 1995 researchers at the National Institutes of Health reported that IGF-1 plays a central role in the progression of many childhood cancers and in the growth of tumours in breast cancer, small cell lung cancer, melanoma and cancers of the pancreas and prostate ( LeRoith, Derek, et al. The role of insulin-like growth factor 1 receptor in cancer. Annals New York Academy of Sciences, Vol. 766, Sept 7, 1995. pp 420-08). On January 23rd, 1998 researchers at the Harvard Medical School released a major study providing conclusive evidence that IGF-1 is a potent risk factor for prostate cancer (Chan, June M et al. Plasma insulin-like growth factor 1 and prostate cancer risk: a prospective study. Science, Vol. 279, Jan 23, 1998, pp 563-66). Other research provides more evidence of IGF-1’s link to breast and colon cancer and a strong link between cancer risk and a high level of IGF-1 is now indisputable.
Also consider when looking at studies or people making recommendations off of studies - LR3 is all bootleg and handled in various ways from the mfgr by third parties who may or may not destroy the delicate proteins involved. For an expensive experiment, it may be OK if you have the money to "waste" but i would not break the bank in hopes of achieving any great gains or results. To the best of my knowledge, Gro-Pep is the only source for it and it is NOT sold for human use. In fact, the stuff that everyone sells is the media grade since it is much cheaper.
Also look into Patrick Arnold and William Llewellyn, and stuff they have written about it, and also empirical data from other members or bodybuilders that have used it.
Here's some quotes from Patrick Arnold.
"IGF-1, administered systemically, has very poor effects on muscle growth actually. There are other interesting uses and benefits of it though"
Regarding localized growth without gut growth:
"it would not stick around long enough in the muscle to really do this. you would have to have a continous infusion into the muscle and then also you would need to have multiple entries into the muscle so that it is evenly distributed. into connective tisse though its different. connective tissue has very poor blood supply so it would stay put for a while. and connective tissue is quite responsive to igf-1
"
"IGF-1 injected intramsucularly will not be able to penetrate into the muscle long and reach concentrations high enough to give localized growth. being water soluble, it will be whisked away by your blood stream very quickly. connective tissue is different. very little blood supply so it will stick around longer. plus connective tissue is more sensitive to lower concentrations of IGf1 than muscle"
"that is why the only real viable IGF-1 therapy that may result in muscle hypertrophy is the gene threapy. this gene therapy uses an engineered virus to insert the gene for making IGF-1 into the nuclei of the muscle. Once there, it pours our IGF-1 into the muscle cell itself"
My post is getting way too long, and I am not focused, I again just want to make sure that you know all sides of the story.