You put people on glucophage as monotherapy, are indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes. Are you sure your sis isn’t a diabtic ? Adults in general, clinically significant responses are not seen at doses below 1500 mg per day. However, a lower recommended starting dose and gradually increased dosage is advised to minimize gastrointestinal symptoms.
The usual starting dose of glucophage is 500 mg twice a day or 850 mg once a day, given with meals. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in divided doses. Patients can also be titrated from 500 mg twice a day to 850 mg twice a day after 2 weeks. For those patients requiring additional glycemic control, glucophage may be given to a maximum daily dose of 2550 mg per day. Doses above 2000 mg may be better tolerated given three times a day with meals. You would never had to go at these dosages due to the fact, we are not diabetics. Diabetes mellitus (DM) is a group of metabolic diseases characterized by high blood sugar levels, which result from defects in insulin secretion, or action, or both. We do not have this problem.
With anemias,a decrease to subnormal levels of previously normal serum Vitamin B12 levels, without clinical manifestations is very low when taking glucophage. However, measurement of hematologic parameters on an annual basis is the standard in patients on glucophage. Certain individuals with inadequate Vitamin B12 appear to be predisposed to developing subnormal Vitamin B12 levels. In these patients, routine serum Vitamin B12 measurements at two- to three-year intervals may be useful.
Tordon, I wasn’t replying anything negative about you in regards to taking glucophage. I’m also very glad you research things before trying them. As with glucophage, I would recommend that you stay away from taking this now. I only recommend this due to the fact; you have DM that runs in your family. If your MD is recommending that your sis be put on it, then her A1C which is a test that can measure your glucose during the last three months must be high. Your MD will not put her on glucophage unless she is DX with DM. If this is the case and I hate to say it, but you are running a very high risk of developing DM in the future. Also, if you are genetically predisaposed to DM, taking insulin or any oral anti-diabetic medications may actually increase your risk more. I have no proof that it may and I doubt I can go through any journal to see if any studies exist. Since a study like that would be unethical.