Proviron® (mesterolone)
Quick overview:
Active Life: 8-12 hours (effects last about 24 hours)
Drug Class: Androgenic Steroid/Anti- Aromatization (Oral)
Average Dose: Men 25-100 mg/day.....Women 25-50 mg/day
Acne: Rare
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Low
Aromatization: None
DHT Conversion: No, it is a derivative of DHT
Decrease HPTA function: No
Proviron® is the Schering brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.
The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.
This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol, oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).
The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with Nolvadex (tamoxifen citrate) or Clomid (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Proviron and 20mg Nolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.
Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a "safe" oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by Schering, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and small glass vials, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Femara, or Aromasin ares actually a much better choice than Proviron though. These drugs were designed specifically as an anti-aromatase, and works much more effectively than anything else we have available.
------
Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics. Proviron is used in school medi-cine to case or cure disturbances caused by a deficiency of male sex hormones. Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testoster-one production. This, however, is not a good idea since Proviron has no effect on the body's own testosterone production but-as men-tioned in the beginning-only reduces or completely eliminates the dysfunctions caused by the testosterone deficiency. These are, in par-ticular, impotence which is mostly caused by an androgen deficiency that can occur after the discontinuance of steroids, and infertility which manifests itself in a reduced sperm count and a reduced sperm quality. Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however, does not con-tribute to the maintenance of strength and muscle mass after the treatment. There are other better suited compounds for this (see HCG, Clomid, and Teslac). For this reason Proviron is unfortunately considered by many to be a useless and unnecessary compound.
You should be aware that Proviron is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the antiestrogen Nolvadex which only blocks the estrogen receptors (see Nolvadex) Proviron already prevents the aromatizing of steroids. Therefore gynecomastia and increased water retention are successfully blocked. Since Proviron strongly suppresses the forming of estrogens no re-bound effect occurs after discontinuation of use of the compound as is the case with, for example, Nolvadex where an aromatization of the steroids is not prevented. One can say that Nolvadex cures the problem of aromatization at its root while Nolvadex simply cures the symptoms. For this reason male athletes should prefer Proviron to Nolvadex. With Proviron the athlete obtains more muscle hard-ness since the androgen level is increased and the estrogen concen-tration remains low. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level of-ten supplement their steroid intake with Proviron resulting in increased muscle hardness. In the past it was common for body-builders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes' appearances at guest performances, seminars and photo sessions. Today Clenbuterol is usually taken over the entire year since possible virilization symp-toms cannot occur which is not yet the case with Proviron. Since Proviron is very effective male athletes usually need only 50-mg/ day which means that the athlete usually takes one 25 mg tablet in the morning and another 25 mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Proviron with Nolvadex (50 mg Proviron/day and 20 mg Nolvadex/day) this will lead to an almost complete suppression of estrogen. Even better results are achieved with 50 mg Proviron/ day and 500 - 1000 mg Teslac/day. Since Teslac is a very expensive compound (see Teslac) most athletes do not consider this com-bination.
The side effects of Proviron in men are low at a dosage of 24 tab--lets/day so that Proviron, taken for example in combination with a steroid cycle, can be used comparatively without risk over several weeks. Since Proviron is well-tolerated by the liver, liver dysfunc-tions do not occur in the given dosages. For athletes who are used to acting under the motto "more is better" the intake of Proviron could have a paradoxical effect. The most common side effect of Proviron is a distinct sexual overstimulation and in some cases continuous penis erection. Since this condition can be painful and lead to possible damages, a lower dosage or discontinu-ing the compound are the only sensible solutions. Female athletes should use Proviron with caution since possible androgenic side ef-fects cannot be excluded. Women who want to give Proviron a try should not take more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no dif-ficulties with Proviron obtain good results with 25 mg Proviron/ day and 20 mg Nolvadex/day and, in combination with a diet, re-port an accelerated fat breakdown and continuously harder muscles.
Proviron is one of the very few steroid hormones which is still suf-ficiently available. The usual price is about $1 per tablet on the black market. All Proviron tablets have one thing in com-mon: they are all indented and on the back have the stamp AX, surrounded by a hexagon.
Proviron, an anabolic steroid, is particularly interesting. I suspect that it not only acts as an antiaromatase but in an unknown DHT-like anti-estrogenic manner. This might involve estrogen receptor downregulation for example. In any case, aromatase inhibition and/or Clomid don’t seem to give the same effect on appearance and muscle hardness as when Proviron is included.
This drug has good binding to the androgen receptor, but in muscle tissue most of it never reaches the androgen receptor because it is enzymatically converted to the diol. Thus, it is not an effective anabolic. It is somewhat effective as an anti-gyno agent, however, and appears to reduce estrogenic bloating if that problem exists.
Proviron reduces either levels of estrogen or the effect of estrogen. Thus, it is useful for avoiding gynecomastia, although it probably should not be relied upon as the sole drug for that. It is not hepatotoxic. It has the usual side effects of anabolic/androgenic steroids, with the added effect that it is particularly prone to cause erections.
-----
MESTORANUM, PLURIVIRON, PROVIRON, VISTIMON.
Found in dosages:-
10, 20, 25 AND 50mg.
Presentation:-
30 DRAGEE PER BOX (PLURIVIRON). 20 AND 50 TABLET BOXES AND BOTTLES.
Anabolic/Androgenic Ratio:-
STRONG ANDROGENIC ACTION WITH ALMOST NON-EXISTENT ANABOLIC PROPERTIES.
Mesterolone is a strong oral androgen derived from DHT. Just as its parent compound, mesterolone cannot in any way aromatise to estrogen. In the medical field mesterolone is normally used to treat varying levels of male sexual dysfunction normally caused by a low endogenous testosterone level. Many users find a return of sexual interest along with decreased frequency of impotence problems. Another plus for mesterolone is that it can also increase sperm count in most (male) users and is often used as a fertility aid because of this. This compound does not get the bodies endocrine system back to normal as it cannot increase endogenous testosterone production, it is merely used as an androgen substitute.
Strangely, Mesterolone has only a very weak anabolic effect, surprising as most androgens have a high accompanying anabolic component such as is the case with testosterone. It is thought that this is due to its relation to DHT that like mesterolone, reduces into inactive metabolites that have no effect on altering muscle cell DNA transcription.
In the past, many athletes have avoided Mesterolone, as it was inaccurately reported to block muscle receptor sites, so making the other compounds stacked alongside it relatively inert. In actuality the opposite is thought to occur. Mesterolone has a VERY high affinity with Steroid Hormone Binding Globulin (SHBG), which is one of the enemies of the steroid user from it attaching itself to steroid molecules, disabling them from delivering their muscle-building message. Since a higher proportion of the SHBG’s are kept "tied up" from Mesterolone use, higher levels of active compounds in the stack are left to do their construction work on muscle tissue, as they are now left in the free and active state.
The most common use of mesterolone in bodybuilding however is as an anti-estrogen. It acts as an anti-aromatase agent, preventing or slowing the conversion of androgens to estrogen. In this author's opinion, an anti-aromatase is much more useful than a simple estrogen blocker such as Tamoxifen, as it is dealing with the cause of estrogen buildup rather than just treating the symptoms of its negative effects. However, many athletes do use mesterolone and tamoxifen concurrently for a double-headed defense against estrogen, as any newly converted estrogen that was missed by the mesterolone is block at target sites by the tamoxifen.
Mesterolone is often added to the steroid users pre-contest array for its low estrogen/high androgenicity, which does well to balance out the more anabolic and less androgenic compounds such as Stanozolol, Oxandrolone and Methenolone. The high androgen level from Mesterolone use bring with it an increase in muscle density and hardness due to the muscle fiber’s ability to draw in more fluid and nutrients.
This compound is well tolerated in males with side effects occurring very rarely with dosages kept at under 100mg daily. Obviously at higher dosages the excess androgens can bring about the normally associated side effects such as oily skin, acne, increased hair growth and accelerated male pattern balding. However, being a DHT derivative, mesterolone is well known for its affect on the male libido and sense of well being, which can only be a positive thing.
Mesterolone is not alpha-alkylated at the C-17 position, so removing any potential liver toxicity. It has in fact 1-methylated in structure as with Methenolone, which is termed the "safest" of all oral steroids, making it a minimal risk. Although C-17 alkylation does allow more of the parent compound to get into the blood, the 1-methylation leads to lower levels but still high enough to do a respectable job.
In women, Mesterolone had been shown to have dramatic effects on the contest ready physique due to the subtle shift in androgen/estrogen ratio and also by making for a promotive environment for fat loss, especially in the problematic hip and thigh areas. They must be careful however, as Mesterolone is a strong androgen making virilisation symptoms a problem such as clitoral enlargement, deepening of the voice, roughened skin texture and menstrual irregularities. This gives rise to most females staying at the 25mg daily dosage range for no more than 4 to 5 weeks at a time, possibly in combination with low dose Tamoxifen therapy for a synergistically greater effect with much less risk.
For men, a typical daily dosage is around the 50-100mg mark, which will be more than sufficient for moderate androgenic cycles to avoid estrogen related side effects. In VERY high dose, super androgen cycles, I would recommend adding moderate amounts of Tamoxifen Citrate and/or Clomiphene Citrate, rather than just upping the Mesterolone dosage.
MENS SUGGESTED DOSAGE: 50-100mg daily when taken as a sole anti-estrogen or 25-50mg daily if taken in conjunction with Tamoxifen and/or Clomiphene.
WOMENS SUGGESTED DOSAGE: No more than 25mg daily for no longer than 4-6 weeks.
-----
Proviron - Mesterolone Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics. Proviron is used in school medicine to ease or cure disturbances eaused by a deficiency of male sex hormones. Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testosterone production. This, however is not a good idea since Proviron has no effect on the body's own testosterone production but-as mentioned in the beginning-only reduces or completely eliminates the dysfunctions caused by the testosterone deficiency. These are in particular impotence which is mostly caused by an androgen deficiency that can occur after the discontinuance of steroids, and infertility which manifests itself in a reduced sperm count and a reduced sperm quality. Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however does not contribute to the maintainance of strength and muscle mass after the treatment. There are other better suited compounds for this (see HCG and Clomid). For this reason Proviron is unfortunately cunsidered by many to be a useless and unnecessary compound.
You should be aware that Proviron is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the antiestrogen Nolvadex which only blocks the estrogen receptors (see Nolvadex) Proviron already prevents the aromatizing of steroids. Therefore gynecomastia and increased water retention are successfully blocked. Since Proviron strongly suppresses the forming of estrogens no rebound effect occurs after discontinuation of use of the compound as is the case with, for example, Nolvadex where an aromatization of the steroids is not prevented. One can say that Nolvadex cures the problem of aromatization at its root while Nolvadex simply cures the symptoms. For this reason male athletes should prefer Proviron to Nolvadex. With Proviron the athlete obtains more muscle hardness since the androgen level is increased and the estrogen concentration remains low. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level often supplement their steroid intake with Proviron resulting in an increased muscle hardness. In the past it was common for bodybuilders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes appearances at guest performances, seminars and photo sessions. Today Clenbuterol is usually taken over the entire year since possible virilization symptoms cannot occur which is not yet the case with Proviron. Since Proviron is very effective male athletes usually need only 50 mg/day which means that the athlete usually takes one 25 mg tablet in the morning and another 25 mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Proviron with Nolvadex (50 mg Proviron/day and 20 mg Nolvadex/day) this will lead to an almost complete suppression of estrogen.
The side effects of Proviron in men are low at a dosage of 2-3 tablets/day so that Proviron, taken for example in combination with a steroid cycle, can be used comparatively without risk over several weeks. Since Proviron is well-tolerated by the liver liver dysfunctions do not occur in the given dosages. For athletes who are used to acting under the motto "more is better" the intake of Proviron could have a paradoxical effect. The most common side effect of Proviron-or in this case, secondary symptom- is in part a distinct sexual overstimulation and in some cases continuous penis erection. Since this condition can be painful and lead to possible damages, a lower dosage or discontinuing the compound are the only sensible solutions. Female athletes should use Proviron with caution since possible androgenic side effects cannot be excluded. Women who want to give Proviron a try should not take more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no difficulties with Proviron obtain good results with 25 mg Proviron/day and 20 mg Nolvadex/day and, in combination with a diet, report an accelerated fat breakdown and continuously harder muscles.
Proviron is one of the very few steroid hormones which is still sufficiently available. The brand name Proviron costs about $35 in Germany and contains fifty 25 mg tablets. Vistimon by Jenapharm costs $ 14 per box and is packaged in two push-through strips of 10 tablets each. Proviron by Asche contains 30 dragees and costs $20.. As one can see all German manufacturers charge about $70 for one 25 mg Mesterolon tablet. This is similar to the generally observed price of $ 1 per tablet on the black market. Since the Spanish and Mexican Proviron are less expensive than the German Proviron (all compounds are by Schering) they are more readily available on the black market. The original price for 20 tablets in Spain, for example, is $ 3.60. Depending on the country of origin Proviron is packaged differently. The German Proviron is offered in small glass vials while the Spanish, Greek, and Mexican versions are included in push-through strips. However, all Proviron tablets have one thing in common: they are all indented and on the back have the stamp AX,surrounded by a hexagon. So far there are no fakes available of either Proviron or its generic compounds.
It is an Estrogen antagonist. It is completely singlestick with all other steroids.
Product Price
Proviron 25mg x 100 tablets by Schering AG.Germany
------
Description:
Proviron is a registrated trademark of Scherling A/G Germany & Schering Mexicanna. Proviron/mesterolone Oral 25 mg Tablets are a multi-purpose Androgenic steroid with anabolic properties designed to be given to men in the early and medopausal stages of life. This steroid is most unique in the world because it is a non-17 Alpha Oral Androgen replacement for males. Provides health, added sex drive, the feeling of well being, vigor and sone qualities of youth. It may be taken over long periods of time. It does not aromatize in fact bodybuilders take this in place of Nolvadex because Proviron is an Estrogen antagonist. It is completely singlestick with all other steroids. Though as the best steroids goes not approved by FDA but Schering world wide sales don?t seem to suffer. Proviron is sold in 37 countries world wide. Sense it unique formula does not shut down the male own hormone production as with the highly androgenic Testosterone Cyponiate and spermogenis is added to not subtracted from. Proviron could medically help 20 to 30 million males who experience male-menopause.
Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics.
Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testosterone production.
Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however does not contribute to the maintainance of strength and muscle mass after the treatment.
Dosage:
Average dose is 1 tablet a day should be sufficient to prevent gynecomastia
Pharmaceutical Name: Mesterolone
Chemical structure: 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one
Molecular weight of base: 304.4716
Effective dose: 25-100 mg / day orally
Average Street-price: $0.80 - 1.50 per 25 mg tab
Available Doses: 10, 20, 25 and 50 mg tabs
Characteristics:
Mesterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion. DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body. When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. It can equally convert back to DHT by way of the same enzyme when low levels of DHT are detected. But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy.
Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.
The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.
Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.
Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.
Mesterolone is generally well liked nonetheless as it delivers very few side-effects in men. In high doses it can cause some virilization symptoms in women. But because of the high level of deactivation and pre-destination in the system (albumin, SHBG, 3bHSD, aromatase) quite a lot of it, if not all simply never reaches the androgen receptor where it would cause anabolic effects, but also side-effects. So its relatively safe. Doses between 25 and 250 mg per day are used with no adverse effects. 50 mg per day is usually sufficient to be effective in each of the four cases we mentioned up above, so going higher really isn't necessary. Unlike what some suggest or believe, its not advised that Proviron be used when not used in conjunction with another steroid, as it too is quite suppressive of natural testosterone, leading to all sorts of future complications upon discontinuation. Ranging from loss of libido or erectile dysfunction all the way up to infertility. One would not be aware of such dangers because Proviron fulfills most of the functions of normal levels of testosterone.
Stacking and Use:
Mesterolone is an oral alkylated steroid. If used primarily as an anti-aromatase drug, using it throughout a longer cycle (10-12 weeks) of injectables may elevate liver values a little bit, though much, much less than one would expect with a 17-alpha-alkylated steroid. Eventhough instead of inhibiting gains, mesterolone may actually contribute to gains. So that's a bit of a shame. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown, but not like 17-alpha alkylation. The reason for the change of position I assume, is because alkylating at the 17-alpha position has been shown to reduce affinity for sex hormone binding proteins. This would in turn decrease its ability to free testosterone. Nonetheless the delivery rate is quite good. Its taken daily in 50-100 mg doses.
The best thing to stack it with is testosterone of course. Its most easily bound to SHBG and albumin, and deactivated for up to 98%. Since the DHT can compete for these structures with higher affinity it would naturally lead to a higher yield of whatever testosterone product you stacked it with. Since DHT levels are notably higher now there is also more stimulation of the androgen receptor causing more strength gains, and because of its affinity for aromatase the overall estrogen level decreases as well. This has as a result that gains are leaner, and once again the overall testosterone yield is increased as less I converted at the aromatase enzyme.
It's of course used in other stacks with products such as methandrostenolone, boldenone and nandrolone to reduce estrogenic activity and increase muscle hardness. The addition of proviron makes boldenone a dead lock for a cutting stack and for some may even make it possible to use nandrolone while cutting, although the use of Winstrol or a receptor antagonist in conjunction is wishful as well. The benefit of adding it to a nandrolone stack is that it may also help you reduce the decrease in libido suffered from nandrolone, since the latter is mostly deactivated by 5-alpha reductase, an enzyme that makes other hormones more androgenic.
Proviron is an anti-aromatase, so obviously anti-estrogens would be futile and redundant. Blood pressure medication for those prone to hypertension may be wise, as this DHT can increase the blood pressure.
Quick overview:
Active Life: 8-12 hours (effects last about 24 hours)
Drug Class: Androgenic Steroid/Anti- Aromatization (Oral)
Average Dose: Men 25-100 mg/day.....Women 25-50 mg/day
Acne: Rare
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Low
Aromatization: None
DHT Conversion: No, it is a derivative of DHT
Decrease HPTA function: No
Proviron® is the Schering brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.
The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.
This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol, oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).
The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with Nolvadex (tamoxifen citrate) or Clomid (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Proviron and 20mg Nolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.
Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a "safe" oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by Schering, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and small glass vials, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Femara, or Aromasin ares actually a much better choice than Proviron though. These drugs were designed specifically as an anti-aromatase, and works much more effectively than anything else we have available.
------
Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics. Proviron is used in school medi-cine to case or cure disturbances caused by a deficiency of male sex hormones. Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testoster-one production. This, however, is not a good idea since Proviron has no effect on the body's own testosterone production but-as men-tioned in the beginning-only reduces or completely eliminates the dysfunctions caused by the testosterone deficiency. These are, in par-ticular, impotence which is mostly caused by an androgen deficiency that can occur after the discontinuance of steroids, and infertility which manifests itself in a reduced sperm count and a reduced sperm quality. Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however, does not con-tribute to the maintenance of strength and muscle mass after the treatment. There are other better suited compounds for this (see HCG, Clomid, and Teslac). For this reason Proviron is unfortunately considered by many to be a useless and unnecessary compound.
You should be aware that Proviron is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the antiestrogen Nolvadex which only blocks the estrogen receptors (see Nolvadex) Proviron already prevents the aromatizing of steroids. Therefore gynecomastia and increased water retention are successfully blocked. Since Proviron strongly suppresses the forming of estrogens no re-bound effect occurs after discontinuation of use of the compound as is the case with, for example, Nolvadex where an aromatization of the steroids is not prevented. One can say that Nolvadex cures the problem of aromatization at its root while Nolvadex simply cures the symptoms. For this reason male athletes should prefer Proviron to Nolvadex. With Proviron the athlete obtains more muscle hard-ness since the androgen level is increased and the estrogen concen-tration remains low. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level of-ten supplement their steroid intake with Proviron resulting in increased muscle hardness. In the past it was common for body-builders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes' appearances at guest performances, seminars and photo sessions. Today Clenbuterol is usually taken over the entire year since possible virilization symp-toms cannot occur which is not yet the case with Proviron. Since Proviron is very effective male athletes usually need only 50-mg/ day which means that the athlete usually takes one 25 mg tablet in the morning and another 25 mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Proviron with Nolvadex (50 mg Proviron/day and 20 mg Nolvadex/day) this will lead to an almost complete suppression of estrogen. Even better results are achieved with 50 mg Proviron/ day and 500 - 1000 mg Teslac/day. Since Teslac is a very expensive compound (see Teslac) most athletes do not consider this com-bination.
The side effects of Proviron in men are low at a dosage of 24 tab--lets/day so that Proviron, taken for example in combination with a steroid cycle, can be used comparatively without risk over several weeks. Since Proviron is well-tolerated by the liver, liver dysfunc-tions do not occur in the given dosages. For athletes who are used to acting under the motto "more is better" the intake of Proviron could have a paradoxical effect. The most common side effect of Proviron is a distinct sexual overstimulation and in some cases continuous penis erection. Since this condition can be painful and lead to possible damages, a lower dosage or discontinu-ing the compound are the only sensible solutions. Female athletes should use Proviron with caution since possible androgenic side ef-fects cannot be excluded. Women who want to give Proviron a try should not take more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no dif-ficulties with Proviron obtain good results with 25 mg Proviron/ day and 20 mg Nolvadex/day and, in combination with a diet, re-port an accelerated fat breakdown and continuously harder muscles.
Proviron is one of the very few steroid hormones which is still suf-ficiently available. The usual price is about $1 per tablet on the black market. All Proviron tablets have one thing in com-mon: they are all indented and on the back have the stamp AX, surrounded by a hexagon.
Proviron, an anabolic steroid, is particularly interesting. I suspect that it not only acts as an antiaromatase but in an unknown DHT-like anti-estrogenic manner. This might involve estrogen receptor downregulation for example. In any case, aromatase inhibition and/or Clomid don’t seem to give the same effect on appearance and muscle hardness as when Proviron is included.
This drug has good binding to the androgen receptor, but in muscle tissue most of it never reaches the androgen receptor because it is enzymatically converted to the diol. Thus, it is not an effective anabolic. It is somewhat effective as an anti-gyno agent, however, and appears to reduce estrogenic bloating if that problem exists.
Proviron reduces either levels of estrogen or the effect of estrogen. Thus, it is useful for avoiding gynecomastia, although it probably should not be relied upon as the sole drug for that. It is not hepatotoxic. It has the usual side effects of anabolic/androgenic steroids, with the added effect that it is particularly prone to cause erections.
-----
MESTORANUM, PLURIVIRON, PROVIRON, VISTIMON.
Found in dosages:-
10, 20, 25 AND 50mg.
Presentation:-
30 DRAGEE PER BOX (PLURIVIRON). 20 AND 50 TABLET BOXES AND BOTTLES.
Anabolic/Androgenic Ratio:-
STRONG ANDROGENIC ACTION WITH ALMOST NON-EXISTENT ANABOLIC PROPERTIES.
Mesterolone is a strong oral androgen derived from DHT. Just as its parent compound, mesterolone cannot in any way aromatise to estrogen. In the medical field mesterolone is normally used to treat varying levels of male sexual dysfunction normally caused by a low endogenous testosterone level. Many users find a return of sexual interest along with decreased frequency of impotence problems. Another plus for mesterolone is that it can also increase sperm count in most (male) users and is often used as a fertility aid because of this. This compound does not get the bodies endocrine system back to normal as it cannot increase endogenous testosterone production, it is merely used as an androgen substitute.
Strangely, Mesterolone has only a very weak anabolic effect, surprising as most androgens have a high accompanying anabolic component such as is the case with testosterone. It is thought that this is due to its relation to DHT that like mesterolone, reduces into inactive metabolites that have no effect on altering muscle cell DNA transcription.
In the past, many athletes have avoided Mesterolone, as it was inaccurately reported to block muscle receptor sites, so making the other compounds stacked alongside it relatively inert. In actuality the opposite is thought to occur. Mesterolone has a VERY high affinity with Steroid Hormone Binding Globulin (SHBG), which is one of the enemies of the steroid user from it attaching itself to steroid molecules, disabling them from delivering their muscle-building message. Since a higher proportion of the SHBG’s are kept "tied up" from Mesterolone use, higher levels of active compounds in the stack are left to do their construction work on muscle tissue, as they are now left in the free and active state.
The most common use of mesterolone in bodybuilding however is as an anti-estrogen. It acts as an anti-aromatase agent, preventing or slowing the conversion of androgens to estrogen. In this author's opinion, an anti-aromatase is much more useful than a simple estrogen blocker such as Tamoxifen, as it is dealing with the cause of estrogen buildup rather than just treating the symptoms of its negative effects. However, many athletes do use mesterolone and tamoxifen concurrently for a double-headed defense against estrogen, as any newly converted estrogen that was missed by the mesterolone is block at target sites by the tamoxifen.
Mesterolone is often added to the steroid users pre-contest array for its low estrogen/high androgenicity, which does well to balance out the more anabolic and less androgenic compounds such as Stanozolol, Oxandrolone and Methenolone. The high androgen level from Mesterolone use bring with it an increase in muscle density and hardness due to the muscle fiber’s ability to draw in more fluid and nutrients.
This compound is well tolerated in males with side effects occurring very rarely with dosages kept at under 100mg daily. Obviously at higher dosages the excess androgens can bring about the normally associated side effects such as oily skin, acne, increased hair growth and accelerated male pattern balding. However, being a DHT derivative, mesterolone is well known for its affect on the male libido and sense of well being, which can only be a positive thing.
Mesterolone is not alpha-alkylated at the C-17 position, so removing any potential liver toxicity. It has in fact 1-methylated in structure as with Methenolone, which is termed the "safest" of all oral steroids, making it a minimal risk. Although C-17 alkylation does allow more of the parent compound to get into the blood, the 1-methylation leads to lower levels but still high enough to do a respectable job.
In women, Mesterolone had been shown to have dramatic effects on the contest ready physique due to the subtle shift in androgen/estrogen ratio and also by making for a promotive environment for fat loss, especially in the problematic hip and thigh areas. They must be careful however, as Mesterolone is a strong androgen making virilisation symptoms a problem such as clitoral enlargement, deepening of the voice, roughened skin texture and menstrual irregularities. This gives rise to most females staying at the 25mg daily dosage range for no more than 4 to 5 weeks at a time, possibly in combination with low dose Tamoxifen therapy for a synergistically greater effect with much less risk.
For men, a typical daily dosage is around the 50-100mg mark, which will be more than sufficient for moderate androgenic cycles to avoid estrogen related side effects. In VERY high dose, super androgen cycles, I would recommend adding moderate amounts of Tamoxifen Citrate and/or Clomiphene Citrate, rather than just upping the Mesterolone dosage.
MENS SUGGESTED DOSAGE: 50-100mg daily when taken as a sole anti-estrogen or 25-50mg daily if taken in conjunction with Tamoxifen and/or Clomiphene.
WOMENS SUGGESTED DOSAGE: No more than 25mg daily for no longer than 4-6 weeks.
-----
Proviron - Mesterolone Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics. Proviron is used in school medicine to ease or cure disturbances eaused by a deficiency of male sex hormones. Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testosterone production. This, however is not a good idea since Proviron has no effect on the body's own testosterone production but-as mentioned in the beginning-only reduces or completely eliminates the dysfunctions caused by the testosterone deficiency. These are in particular impotence which is mostly caused by an androgen deficiency that can occur after the discontinuance of steroids, and infertility which manifests itself in a reduced sperm count and a reduced sperm quality. Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however does not contribute to the maintainance of strength and muscle mass after the treatment. There are other better suited compounds for this (see HCG and Clomid). For this reason Proviron is unfortunately cunsidered by many to be a useless and unnecessary compound.
You should be aware that Proviron is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the antiestrogen Nolvadex which only blocks the estrogen receptors (see Nolvadex) Proviron already prevents the aromatizing of steroids. Therefore gynecomastia and increased water retention are successfully blocked. Since Proviron strongly suppresses the forming of estrogens no rebound effect occurs after discontinuation of use of the compound as is the case with, for example, Nolvadex where an aromatization of the steroids is not prevented. One can say that Nolvadex cures the problem of aromatization at its root while Nolvadex simply cures the symptoms. For this reason male athletes should prefer Proviron to Nolvadex. With Proviron the athlete obtains more muscle hardness since the androgen level is increased and the estrogen concentration remains low. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level often supplement their steroid intake with Proviron resulting in an increased muscle hardness. In the past it was common for bodybuilders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes appearances at guest performances, seminars and photo sessions. Today Clenbuterol is usually taken over the entire year since possible virilization symptoms cannot occur which is not yet the case with Proviron. Since Proviron is very effective male athletes usually need only 50 mg/day which means that the athlete usually takes one 25 mg tablet in the morning and another 25 mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Proviron with Nolvadex (50 mg Proviron/day and 20 mg Nolvadex/day) this will lead to an almost complete suppression of estrogen.
The side effects of Proviron in men are low at a dosage of 2-3 tablets/day so that Proviron, taken for example in combination with a steroid cycle, can be used comparatively without risk over several weeks. Since Proviron is well-tolerated by the liver liver dysfunctions do not occur in the given dosages. For athletes who are used to acting under the motto "more is better" the intake of Proviron could have a paradoxical effect. The most common side effect of Proviron-or in this case, secondary symptom- is in part a distinct sexual overstimulation and in some cases continuous penis erection. Since this condition can be painful and lead to possible damages, a lower dosage or discontinuing the compound are the only sensible solutions. Female athletes should use Proviron with caution since possible androgenic side effects cannot be excluded. Women who want to give Proviron a try should not take more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no difficulties with Proviron obtain good results with 25 mg Proviron/day and 20 mg Nolvadex/day and, in combination with a diet, report an accelerated fat breakdown and continuously harder muscles.
Proviron is one of the very few steroid hormones which is still sufficiently available. The brand name Proviron costs about $35 in Germany and contains fifty 25 mg tablets. Vistimon by Jenapharm costs $ 14 per box and is packaged in two push-through strips of 10 tablets each. Proviron by Asche contains 30 dragees and costs $20.. As one can see all German manufacturers charge about $70 for one 25 mg Mesterolon tablet. This is similar to the generally observed price of $ 1 per tablet on the black market. Since the Spanish and Mexican Proviron are less expensive than the German Proviron (all compounds are by Schering) they are more readily available on the black market. The original price for 20 tablets in Spain, for example, is $ 3.60. Depending on the country of origin Proviron is packaged differently. The German Proviron is offered in small glass vials while the Spanish, Greek, and Mexican versions are included in push-through strips. However, all Proviron tablets have one thing in common: they are all indented and on the back have the stamp AX,surrounded by a hexagon. So far there are no fakes available of either Proviron or its generic compounds.
It is an Estrogen antagonist. It is completely singlestick with all other steroids.
Product Price
Proviron 25mg x 100 tablets by Schering AG.Germany
------
Description:
Proviron is a registrated trademark of Scherling A/G Germany & Schering Mexicanna. Proviron/mesterolone Oral 25 mg Tablets are a multi-purpose Androgenic steroid with anabolic properties designed to be given to men in the early and medopausal stages of life. This steroid is most unique in the world because it is a non-17 Alpha Oral Androgen replacement for males. Provides health, added sex drive, the feeling of well being, vigor and sone qualities of youth. It may be taken over long periods of time. It does not aromatize in fact bodybuilders take this in place of Nolvadex because Proviron is an Estrogen antagonist. It is completely singlestick with all other steroids. Though as the best steroids goes not approved by FDA but Schering world wide sales don?t seem to suffer. Proviron is sold in 37 countries world wide. Sense it unique formula does not shut down the male own hormone production as with the highly androgenic Testosterone Cyponiate and spermogenis is added to not subtracted from. Proviron could medically help 20 to 30 million males who experience male-menopause.
Proviron is a synthetic, orally effective androgen which does not have any anabolic characteristics.
Many athletes, for this reason, often use Proviron at the end of a steroid treatment in order to increase the reduced testosterone production.
Proviron is therefore taken during a steroid administration or after discontinuing the use of the steroids, to eliminate a possible impotency or a reduced sexual interest. This, however does not contribute to the maintainance of strength and muscle mass after the treatment.
Dosage:
Average dose is 1 tablet a day should be sufficient to prevent gynecomastia
Pharmaceutical Name: Mesterolone
Chemical structure: 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one
Molecular weight of base: 304.4716
Effective dose: 25-100 mg / day orally
Average Street-price: $0.80 - 1.50 per 25 mg tab
Available Doses: 10, 20, 25 and 50 mg tabs
Characteristics:
Mesterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion. DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body. When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. It can equally convert back to DHT by way of the same enzyme when low levels of DHT are detected. But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy.
Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.
The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.
Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.
Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.
Mesterolone is generally well liked nonetheless as it delivers very few side-effects in men. In high doses it can cause some virilization symptoms in women. But because of the high level of deactivation and pre-destination in the system (albumin, SHBG, 3bHSD, aromatase) quite a lot of it, if not all simply never reaches the androgen receptor where it would cause anabolic effects, but also side-effects. So its relatively safe. Doses between 25 and 250 mg per day are used with no adverse effects. 50 mg per day is usually sufficient to be effective in each of the four cases we mentioned up above, so going higher really isn't necessary. Unlike what some suggest or believe, its not advised that Proviron be used when not used in conjunction with another steroid, as it too is quite suppressive of natural testosterone, leading to all sorts of future complications upon discontinuation. Ranging from loss of libido or erectile dysfunction all the way up to infertility. One would not be aware of such dangers because Proviron fulfills most of the functions of normal levels of testosterone.
Stacking and Use:
Mesterolone is an oral alkylated steroid. If used primarily as an anti-aromatase drug, using it throughout a longer cycle (10-12 weeks) of injectables may elevate liver values a little bit, though much, much less than one would expect with a 17-alpha-alkylated steroid. Eventhough instead of inhibiting gains, mesterolone may actually contribute to gains. So that's a bit of a shame. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown, but not like 17-alpha alkylation. The reason for the change of position I assume, is because alkylating at the 17-alpha position has been shown to reduce affinity for sex hormone binding proteins. This would in turn decrease its ability to free testosterone. Nonetheless the delivery rate is quite good. Its taken daily in 50-100 mg doses.
The best thing to stack it with is testosterone of course. Its most easily bound to SHBG and albumin, and deactivated for up to 98%. Since the DHT can compete for these structures with higher affinity it would naturally lead to a higher yield of whatever testosterone product you stacked it with. Since DHT levels are notably higher now there is also more stimulation of the androgen receptor causing more strength gains, and because of its affinity for aromatase the overall estrogen level decreases as well. This has as a result that gains are leaner, and once again the overall testosterone yield is increased as less I converted at the aromatase enzyme.
It's of course used in other stacks with products such as methandrostenolone, boldenone and nandrolone to reduce estrogenic activity and increase muscle hardness. The addition of proviron makes boldenone a dead lock for a cutting stack and for some may even make it possible to use nandrolone while cutting, although the use of Winstrol or a receptor antagonist in conjunction is wishful as well. The benefit of adding it to a nandrolone stack is that it may also help you reduce the decrease in libido suffered from nandrolone, since the latter is mostly deactivated by 5-alpha reductase, an enzyme that makes other hormones more androgenic.
Proviron is an anti-aromatase, so obviously anti-estrogens would be futile and redundant. Blood pressure medication for those prone to hypertension may be wise, as this DHT can increase the blood pressure.