Are you referencing the fact that it proliferated cancer cells in the rat study? Even though they mention that was in doses of 100-1000x the normal doses, they still say it can promote cancer at normal doses as well. Personally, I will never run it again. If you did, never run it without a COX-2 inhibitor. Look into Telmisartan or GFT505, they are similar in structure and mechanism, but far less toxic. The WADA has even stepped in warning it's athletes of its harmful black market use. Just my opinion, but i think it has A LOT of testing to go till I ever put this in my body. GlaxoSmithKline sold it to a Canadian company so we will see what they do with it.