- Apr 2, 2009
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By: chemicalwarrior
I'm lifting this from a post I made (Jacshelb on rxmuscle.com) a few months ago while trying to understand the purpose, effectiveness and function of all the different igf-1 drugs available. It is a very very confusing topic. Since writing this I have gained a bit more understanding about what is effective and what isn't. My views have changed a little here and there, but the basic premise of this article is still the same. I'd like you to take a read through it and make up your own mind. Go out there and research other sources of info. as well. But, what I believe I offer here is a distilled understanding of the basics about these drugs.
Here are a few things I want to clear up before you read the big article though. If you take nothing else away, consider these bullet points at the very least:
- Igf1-lr3 is a good glucose disposal agent similar to a fast acting insulin but will not have a great effect on hyperplasia due to its altered chemical structure (bio-identical igf-1 is 70 amino acids and lr3 is altered and comprises of 83 amino acids in its structure). I have been told that it has no impact, or very little on insulin sensitivity- which, if true offers an advantage over using straight insulin and would justify its price. But, it shouldn't be confused with bio-identical, original igf-1!
- Igf2-lr3 is a grey area. I've been told that there are no receptors for this compound within muscle. Though I suspect it will attach and activate igf-1 receptors anyway. How effectively? I don't know. I'll stick with some other choices myself. Also, it is supposedly 70 amino acid sequence- so not a true lr3. Weird.
- PEG-MGF Long acting version of straight mgf. MGF is produced only within muscle cells themselves under certain circumstances. It is never circulating throughout your body "systemically." Therefore, much of what has been written on the use of mgf/peg-mgf for bodybuilders is not accurate because studies in the lab were done virally- by inducing the response within the cells, not injection! So, while we may get some "bleed through" into the muscle cells themselves, it is not going to be the holy grail of igf-1 drugs that research quoted in may places would have you believe.
Peg-mgf tends to act similar to igf-1 when it attaches to igf-1 receptors. So, that brings up the question of it is even favorable to use it specifically in the way that we want to use mgf for? MGF is generally used to initiate activation of satellite cells. But, igf-1 stops this process with its own process "differentiation"- where igf-1 tells the cells to "become muscle." If mgf/peg-mgf is acting "like" igf-1 at the receptor site, then it may be signalling differentiation to happen and therefore cutting-short the activation cycle we're trying to create with mgf in the first place! Clear as mud? Good.
Long story short- mgf/peg-mgf is a mixed bag. You don't know exactly what you are going to get from these drugs: maybe some satellite cell activation, maybe some igf-1 type action, glucose disposal? Who knows. More and more I'm coming to believe that maybe the best way to induce satellite cell activation is just hard eccentric weight training and then use des (1-3) igf-1 to finish off the process post workout (1 hr) with differentiation. More theories on that to come.
- DES (1-3) igf-1- Still my best bet for a good igf-1 drug. It is short acting, but quite effective at what we want it to do. It is resistant to igf-1 binding proteins and we actually want it to just provide differentiation- get in and get out. That's all igf-1 drugs are really for in my opinion.
Anyway, take a look through the mini-novel below for an entertaining read. Remember that I'm no chemist, scientist or doctor. Just a semi-educated gym rat trying to piece all of this together.
I'm lifting this from a post I made (Jacshelb on rxmuscle.com) a few months ago while trying to understand the purpose, effectiveness and function of all the different igf-1 drugs available. It is a very very confusing topic. Since writing this I have gained a bit more understanding about what is effective and what isn't. My views have changed a little here and there, but the basic premise of this article is still the same. I'd like you to take a read through it and make up your own mind. Go out there and research other sources of info. as well. But, what I believe I offer here is a distilled understanding of the basics about these drugs.
Here are a few things I want to clear up before you read the big article though. If you take nothing else away, consider these bullet points at the very least:
- Igf1-lr3 is a good glucose disposal agent similar to a fast acting insulin but will not have a great effect on hyperplasia due to its altered chemical structure (bio-identical igf-1 is 70 amino acids and lr3 is altered and comprises of 83 amino acids in its structure). I have been told that it has no impact, or very little on insulin sensitivity- which, if true offers an advantage over using straight insulin and would justify its price. But, it shouldn't be confused with bio-identical, original igf-1!
- Igf2-lr3 is a grey area. I've been told that there are no receptors for this compound within muscle. Though I suspect it will attach and activate igf-1 receptors anyway. How effectively? I don't know. I'll stick with some other choices myself. Also, it is supposedly 70 amino acid sequence- so not a true lr3. Weird.
- PEG-MGF Long acting version of straight mgf. MGF is produced only within muscle cells themselves under certain circumstances. It is never circulating throughout your body "systemically." Therefore, much of what has been written on the use of mgf/peg-mgf for bodybuilders is not accurate because studies in the lab were done virally- by inducing the response within the cells, not injection! So, while we may get some "bleed through" into the muscle cells themselves, it is not going to be the holy grail of igf-1 drugs that research quoted in may places would have you believe.
Peg-mgf tends to act similar to igf-1 when it attaches to igf-1 receptors. So, that brings up the question of it is even favorable to use it specifically in the way that we want to use mgf for? MGF is generally used to initiate activation of satellite cells. But, igf-1 stops this process with its own process "differentiation"- where igf-1 tells the cells to "become muscle." If mgf/peg-mgf is acting "like" igf-1 at the receptor site, then it may be signalling differentiation to happen and therefore cutting-short the activation cycle we're trying to create with mgf in the first place! Clear as mud? Good.
Long story short- mgf/peg-mgf is a mixed bag. You don't know exactly what you are going to get from these drugs: maybe some satellite cell activation, maybe some igf-1 type action, glucose disposal? Who knows. More and more I'm coming to believe that maybe the best way to induce satellite cell activation is just hard eccentric weight training and then use des (1-3) igf-1 to finish off the process post workout (1 hr) with differentiation. More theories on that to come.
- DES (1-3) igf-1- Still my best bet for a good igf-1 drug. It is short acting, but quite effective at what we want it to do. It is resistant to igf-1 binding proteins and we actually want it to just provide differentiation- get in and get out. That's all igf-1 drugs are really for in my opinion.
Anyway, take a look through the mini-novel below for an entertaining read. Remember that I'm no chemist, scientist or doctor. Just a semi-educated gym rat trying to piece all of this together.