- Aug 10, 2013
- 14
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Was told to post this here from Pro Muscle
Background: I have been trying to lower myostatin for years trying all types of things such as Shrna, follistatin, cdna, megadose HDACs, HMB, Broccoli, mustard seeds, humanofort etc. to no avail.
Study:
I actually read a post of mine years back about EGCG and a pubmed study showing that i EGCG (from green tea) inhibits Smad3 and promotes Smad7 signalling. From what I understand myostatin exerts it's negative effect on muscle growth via Smad3 signalling, and Smad7 actually inhibits myostatin activity.
Problem:
Back then (2010) I gave up due to the fact that oral bioavailability was low and the amount needed would be toxic. I would need about 4 grams orally of pure EGCG each day.
Solution:
I never considered home brewing and just recently read up on it. I was always scared of infection but learned from my readings here as long as you are somewhat clean there will be no problems. Heck rec users use cigarette filters and cotton.
So now I thought why not make an injectable. I would only need about 400mg a day.
Questions:
Is finding out the concentration just trial and error? I know EGCG compared to testosterone has a high molecular weight and high melting point.
But Testosterone which is non polar can still be made in high concentrations by some of the vets here. I would need to get 100-400 mg/ml. I only know once place that sells it and at only 10mg/ml. Any advice on how to brew this stuff?
The best I can find is powders at 50% purity of EGCG. The other compounds seem to be tolerable in the dosage needed. Does anyone see any harm in this? As long as the powder in run though a .22 whatman to remove the bacteria and small particles would this be fine? If you google EGCG and look at the labels, I do not see any harmful or fatal amounts of substance to inject.
Any comments? I can log this if it interests anyone. I am surprised this has not been done and leads me to ask here to see if I am missing something. I am thinking even if it doesn't work it can make an amazing fat burner.
Thanks for reading the long post.
Background: I have been trying to lower myostatin for years trying all types of things such as Shrna, follistatin, cdna, megadose HDACs, HMB, Broccoli, mustard seeds, humanofort etc. to no avail.
Study:
I actually read a post of mine years back about EGCG and a pubmed study showing that i EGCG (from green tea) inhibits Smad3 and promotes Smad7 signalling. From what I understand myostatin exerts it's negative effect on muscle growth via Smad3 signalling, and Smad7 actually inhibits myostatin activity.
Problem:
Back then (2010) I gave up due to the fact that oral bioavailability was low and the amount needed would be toxic. I would need about 4 grams orally of pure EGCG each day.
Solution:
I never considered home brewing and just recently read up on it. I was always scared of infection but learned from my readings here as long as you are somewhat clean there will be no problems. Heck rec users use cigarette filters and cotton.
So now I thought why not make an injectable. I would only need about 400mg a day.
Questions:
Is finding out the concentration just trial and error? I know EGCG compared to testosterone has a high molecular weight and high melting point.
But Testosterone which is non polar can still be made in high concentrations by some of the vets here. I would need to get 100-400 mg/ml. I only know once place that sells it and at only 10mg/ml. Any advice on how to brew this stuff?
The best I can find is powders at 50% purity of EGCG. The other compounds seem to be tolerable in the dosage needed. Does anyone see any harm in this? As long as the powder in run though a .22 whatman to remove the bacteria and small particles would this be fine? If you google EGCG and look at the labels, I do not see any harmful or fatal amounts of substance to inject.
Any comments? I can log this if it interests anyone. I am surprised this has not been done and leads me to ask here to see if I am missing something. I am thinking even if it doesn't work it can make an amazing fat burner.
Thanks for reading the long post.