I have long been concerned about the dangers of excessive IGF1. To that end I found this article.
There is a big difference between Growth Hormone, and IGF-1. The fact is, indeed, that Growth Hormone is broken down in the liver, and produces IGF-1(Insulin Growth Factor). And yes, this particular substance is mostly responsible for muscle growth. The good thing about IGF-1 is that it does not bind into bone cells, or even affect bone cells growth, and so does not give over many years that square face look (which i doubt anyone going for that level anyway would care about such a trivial matter) HOWEVER, IGF-'s catastrophic side effect, is Cancer. IGF-1 binds to the receptors of Cancer cells, and highly promotes cancer cell growth. One will argue; well growth hormone produces IGF-1 in the liver, isn't it the same? No. Growth hormone has many, many effects on the body, one of which is producing RECEPTORS for IGF-1 to BIND with. So it does produce IGF-1, but it also produces receptors that bind with IGF-1, which is in a way countering the negative side effects of IGF-1.
My question is this, does MK 677 cause the liver to produce more GH thereby countering the negative effects of elevated IGF1?