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I've seen people wearing gloves have grip issues when they stop, but that's the only time. Now some dumbells I've also noticed are slim an ill throw a wrist strap over it. But I've never noticed a harder or softer grip based on size of handle.
A good case is rock climbers who develop an incredible grip thru regular climbing. They make exercisers for that but every climber I know say they don't use them.