I like to totally bomb each muscle group. Yesterday I tortured my legs with deadlifts, standing squats, 45 deg. leg press, hack squats, seated calf raises, horizontal calf raises, leg curls, and a couple of cable exercises. I'll take the weekend off and Monday I'll put my upper body thru hell and back. I basically just work whichever muscles that aren't sore at the time - doing some cardio in between. I believe in hitting the muscles from as many different angles as possible - so that they will grow 3-dimensionally. Heavy weight and low reps for compound movements such as deadlift, squat, and bench press - and lighter weight / higher reps for isolated moves such as bicep curl, calf raise, and tricep pull-down. For me the only difference in my workouts when I'm juicin is that my muscles will stand up to more abuse before failing. I also believe in never stopping until the point of complete and total failure has been reached. JMHO.