Doctors undoubtedly recognize that when HCG is taken at too high a dosage OR for too long it can desensitize the LH receptor." "Its intake, is however limited to only 16 days."
This is just like anything is the body. Too much LH = LH suppression and desensitization to avoid too high of levels. Moral is: too high of a dose can cause problems and that is why I (notice that I did not say doctors from the 1980's) recommend doses of <250iu per day - the idea (in my mind) is to replace and nothing more. a recent study showed that 250iu everyother day was understimulating compared to baseline, while 500iu EOD was just a little too stimulating. (of note I have never seen that 16 days rec. only 14, 28, 84 days. hmm.
Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidgenesis. Freeman DA, Ascoli M Proc Natl Acad Sci USA 1981 Oct; 78 (10):6309-13.
A nice read on a controlled study not using humans. Doses of 100x recommended HCG use, which happens to be in itself about 3 times too high (according to latest studies, but I know mike likes his PDR) Sure too high of a dose caused resistance to hcg by lowering LH receptors to avoid imbalance.
Could too long mean an 8 week cycle, when its suggested use is 16 days? Just putting some info out there many a bodybuilders have used HCG like this for decades
Again where's this 16 days come from? I'm just curious as it has no real relavence. Latest techniques are using more..... up-to-date. sure people have been following old-school doctrine for decades, so have doctors and that damn PDR.
Oh yea no offense but good luck trying to get 143 iu out of a 5000 iu single use glass vial. Imagine spending all night trying to eyeball that into IM pin.
Never personally seen a pre-made HCG amp, just the 1000, 2000, 5000, 10000iu dry ones that you add water to. In that case to get 143iu you would add 3.5ml of water to your amp and shoot 1/10cc or whatever.
Listen, steroids are not studied much as far as benefits good for physique-enhancement, so let's take the information we have and use it to the best of our judgement. I am in no way saying that you are wrong regarding not using it during a cycle, just that your reasoning is. Some do it post-cycle (which is really a pre-cycle as their exogenous aas are still too high) some do it during. Their are people on HRT that take 1000iu everyweek for years....and they still respond to LH. I do not wish to argue anymore and the quotes are getting old and to top it all off - I do not even recommend hcg use at all. I use it occassionally when my nuts start climbing inside and get discomfort (yes, low dosages - usually 200iu/day for 20 days) but post cycle hcg makes no sense to me. Sorry rambling.
Mike does agree with that one quote of 16 days being the limit, so if you don't know where it came from, he should.
Hey about that 50mg clomid EOD, I've read that before, tried it, didn't work. Is/does it work for anyone else; I've never seen anyone say that it works or any studies, just people recommending it. Seriously shouldn't any serm or ai work too? I don't know, but do not see why not.