Sorry for the lack of updates guys...but i'm just re-reading this article that our boy TRUEGRIT posted by Mike Arnold a while back. Usually cant stand articles by Mike Arnold but this is a great read and great info on mk677
"One SARM that has become immensely popular over the last few months is MK-677. Lacking the characteristic “steroid-like” effects of previously released SARMs, MK-677 is not utilized as a muscle builder but is first and foremost a growth hormone secretagogue. While traditional GH peptides have done a great job at offering a solution to the hefty price tag and quality control issues facing black market growth hormone, the biggest knock against these products has always been their comparatively short active lives within the body.
Aside from CJC-1295 DAC, which needs to be used at fairly high dosages in order to provide meaningful increases in GH (thereby narrowing the cost cap between CJC and exogenous growth hormone), the other GH peptides need to be administered multiple times daily in order to obtain worthwhile elevations on GH, and oftentimes, they need to be combined with other GH peptides. In the minds of many, this can be a real hassle, causing them to forego their use altogether.
In this sense, MK-677 supplies a distinct advantage. Rather than providing a short, single burst of growth hormone, MK-677 works in pulsatile fashion, delivering up to a dozen bursts of GH over a 24 hour period. When dosed at 25 mg daily, user lab work indicates that one would need to administer roughly 2.5-4 IU of GH per day (or inject GHRP-2 & ModGRF1-29 at a dose of 100-200 mcg each, 3X/day) in order to experience the comparable increase in IGF-1 levels; the most accurate measure of GH production. Being that MK-677 only needs to be administered once per day, this is pretty impressive, especially when one considers that this compound works in a dose-dependent fashion—meaning that higher dosages will provide even greater elevations in GH/IGF-1 levels.
With MK-677 being a GHRP-mimetic, in theory, it should stack very well with a long-acting GHRH such as CJC-1295 DAC. Fortunately, we don’t have to wait for clinical research to validate this hypothesis, as user lab work has already shown the ability of this combo to elevate IGF-1 levels to over 600 in some users—a massive increase, to say the least. While we can’t discount the possibility of these readings being obtained with the added assistance of exogenous growth hormone or other drugs (as this lab work was not conducted in a clinical setting), as more and more anecdotal evidence begins to accumulate, such results will be difficult to deny.
Regardless, MK-677 has proven, in my opinion, to be one of the best GH secretagogues on the market today, due to its GH elevating potency, ease of use, and affordable price. For some, the fact that it does not have to be injected further adds to its allure. As one of the only highly effective, orally active GH releasers, it opens up a whole new world of possibilities to non-needle using fitness and bodybuilding enthusiasts.
For those of you who have been around long enough to remember the GH peptide cortisol and prolactin scare off the mid-2000’s, you will be pleased to read that MK-677 only results in minimal, transient increases in these 2 hormones, with level reverting back to baseline within 8 days of initiating use. Even during the brief period of elevation, levels never ventured outside of the normal range, making any concerns associated with this short-term elevation a non-issue.
Lastly, MK-677, unlike several of our other GH peptides, does not result in desensitization, even after long-term use. In fact, one study revealed that IGF-1 levels continued to rise between the 6 and 12-month mark, demonstrating an improved response with extended use. All in all, it is hard to find fault with this stuff, aside from perhaps its appetite-stimulating effect, but depending on one’s goals/needs, this could very well end up being a positive characteristic."